Shopping Cart

Your shopping cart is currently empty

Isoscopoletin

Name: Isoscopoletin
Brand: TargetMol
SKU: T3815
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T3815Cas No. 776-86-3

Alias 7-Methoxyesculetin, 6-Hydroxy-7-methoxycoumarin

Isoscopoletin (7-Methoxyesculetin) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 6, 7-dimethoxy-2h-chromen-2-one.

Isoscopoletin

Copy Product Info

😃Good

Purity: 99.96%

Catalog No. T3815Alias 7-Methoxyesculetin, 6-Hydroxy-7-methoxycoumarinCas No. 776-86-3

Isoscopoletin (7-Methoxyesculetin) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 6, 7-dimethoxy-2h-chromen-2-one.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$92	In Stock	In Stock
50 mg	$133	-	In Stock
100 mg	$198	-	In Stock
200 mg	$295	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Isoscopoletin AI Summary

Isoscopoletin exhibits a range of bioactivities across various biological targets. It acts as an inhibitor of 15-lipoxygenase (15LOX) with an IC50 value of 15100.0 nM in rabbit reticulocytes, without significant inhibition of 5LOX or human recombinant COX2. It inhibits xanthine oxidase with an IC50 of 138000.0 nM and demonstrates anti-inflammatory activity in human neutrophils by inhibiting fMLP-induced superoxide release, showing an IC50 of 77520.0 nM. The compound induces strand scission in pBR322 DNA, converting supercoiled to nicked forms, especially in the presence of Cu2+, with variable activity at different concentrations (42.0% at 1000 uM, 26.0% at 500 uM, 14.0% at 250 uM), while activity without Cu2+ is minimal (2.0% at 1000 uM). Isoscopoletin inhibits human recombinant aldose reductase 1 (IC50 of 56200.0 nM) and kidney aldose reductase 2 (IC50 of 101000.0 nM) but shows greater inhibition of sorbitol dehydrogenase (IC50 > 250000.0 nM). It selectively inhibits Polymerase Kappa with an IC50 of 23778.1 nM and exhibits 28.07% inhibition of electric eel acetylcholinesterase (AChE) at 2 mg/ml, and 3.87% inhibition of horse butyrylcholinesterase (BChE) at the same concentration. In terms of carbonic anhydrase enzymes, the compound exhibits varying Ki values: 14000.0 nM for CA1, 7370.0 nM for CA9, 5270.0 nM for CA13, and 4140.0 nM for CA12, but shows weaker inhibition of CA2 (Ki > 100000.0 nM). It inhibits mouse brain monoamine oxidase with an IC50 of 32200000.0 nM and demonstrates over 30.0% inhibition of mushroom tyrosinase at 100 uM. Furthermore, Isoscopoletin shows anti-austerity activity against nutrient-deprived human PANC1 cells with a PC50 value of 26.9 uM, and exhibits affinity for human Mcl-1 protein, displacing a specific peptide with a Ki of 15870.0 nM and an IC50 of 51480.0 nM, suggesting potential modulation of Mcl-1 function..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoscopoletin (7-Methoxyesculetin) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 6, 7-dimethoxy-2h-chromen-2-one.
Synonyms	7-Methoxyesculetin, 6-Hydroxy-7-methoxycoumarin

Chemical Properties

Molecular Weight	192.17
Formula	C₁₀H₈O₄
Cas No.	776-86-3
Smiles	COc1cc2oc(=O)ccc2cc1O
Relative Density.	1.37 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

DMSO: 35 mg/mL (182.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2037 mL	26.0186 mL	52.0373 mL	260.1863 mL
5 mM	1.0407 mL	5.2037 mL	10.4075 mL	52.0373 mL
10 mM	0.5204 mL	2.6019 mL	5.2037 mL	26.0186 mL
20 mM	0.2602 mL	1.3009 mL	2.6019 mL	13.0093 mL
50 mM	0.1041 mL	0.5204 mL	1.0407 mL	5.2037 mL
100 mM	0.0520 mL	0.2602 mL	0.5204 mL	2.6019 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc