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Anti-TFPI Antibody (4D905)
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Catalog No. TMAY-03128
Alias tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), TFPI1, TFI, LACI, EPI
Anti-TFPI Antibody (4D905) is a Rabbit antibody targeting TFPI. Anti-TFPI Antibody (4D905) can be used in ELISA(Det).
Anti-TFPI Antibody (4D905)
Anti-TFPI Antibody (4D905)
😃Good
Catalog No. TMAY-03128Alias tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), TFPI1, TFI, LACI, EPI
Anti-TFPI Antibody (4D905) is a Rabbit antibody targeting TFPI. Anti-TFPI Antibody (4D905) can be used in ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $92 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA(Det) Reactivity: Mouse |
| Alias | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), TFPI1, TFI, LACI, EPI |
| Ig Type | Rabbit IgG |
| Clone | 4D905 |
| Reactivity | Mouse |
| Application | ELISA(Det) |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TFPI (rM TFPI ; TMPY-00928; NP_035706.1; Met1-Lys289). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis. |
| Conjucates | Unconjugated |
| Others Formats | HRP |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Mouse TFPI Protein (TMPY-00928) |
| Antigen Species | Mouse |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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