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Hu7691

Name: Hu7691
Brand: TargetMol
SKU: T39899
Rating: 4.5 (1 reviews)

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Catalog No. T39899Cas No. 2360523-76-6

Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation.

Hu7691

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Purity: 99.81%

Catalog No. T39899Cas No. 2360523-76-6

Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	Inquiry	1-2 weeks	1-2 weeks
5 mg	Inquiry	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Hu7691 is an orally active, selective, and potent Akt inhibitor that targets Akt1, Akt2, and Akt3, while also inhibiting neuroblastoma cell proliferation and inducing their differentiation.
Targets&IC50	PKA:11 nM, Akt2:97.5 nM, RSK1:756 nM, Akt1:4.0 nM, Akt3:28 nM, ROCK1:354 nM, p70 S6K:229 nM, PKCη:629 nM
In vitro	Hu7691 exhibits anti-proliferative and neurogenic effects on various neuroblastoma cell lines. This includes neurite outgrowth, cell cycle arrest, and differentiation mRNA markers, further elucidating the differentiation-inducing effects of Hu7691[3].
In vivo	For a repeated dose toxicity study of Hu7691 in male and female Sprague Dawley (SD) rats over 14 consecutive days, the results indicated the following dosages: male rats received daily doses of 12.5, 50, 100, and 150 mg/kg, while female rats received daily doses of 12.5, 25, 50, and 75 mg/kg. Toxicity assessment revealed potential target organs including the spleen, thymus, and gastrointestinal tract[2].

Chemical Properties

Molecular Weight	450.88
Formula	C₂₂H₂₂ClF₃N₄O
Cas No.	2360523-76-6
Smiles	N(C(=O)C1=C(F)C=C(C=C1)C2=CC=NN2C)[C@H]3[C@@H](CCNC3)C4=CC(F)=C(F)C=C4.Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (177.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (11.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2179 mL	11.0894 mL	22.1789 mL	110.8943 mL
5 mM	0.4436 mL	2.2179 mL	4.4358 mL	22.1789 mL
10 mM	0.2218 mL	1.1089 mL	2.2179 mL	11.0894 mL
20 mM	0.1109 mL	0.5545 mL	1.1089 mL	5.5447 mL
50 mM	0.0444 mL	0.2218 mL	0.4436 mL	2.2179 mL
100 mM	0.0222 mL	0.1109 mL	0.2218 mL	1.1089 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc