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SU056

Name: SU056
Brand: TargetMol
SKU: T67741
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67741Cas No. 2376580-08-2

SU056 is a YB-1 inhibitor that interacts with YB-1, inhibiting downstream proteins and pathways. It can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells.

SU056

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Purity: 99.89%

Catalog No. T67741Cas No. 2376580-08-2

SU056 is a YB-1 inhibitor that interacts with YB-1, inhibiting downstream proteins and pathways. It can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$249	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SU056 is a YB-1 inhibitor that interacts with YB-1, inhibiting downstream proteins and pathways. It can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells.
In vitro	SU056 ( 0-10 μ M, 48 hours) inhibits the growth of OVCAR3/4/5/8, SKOV3, and ID8 cells. SU056 (1 μ M, 5-8 days) inhibits colony formation in OVCAR-8 and ID8 cells in a dose-dependent manner. SU056 (1-5 μ M, 6 hours) blocks OVCAR8, SKOV3 and ID8 cells in sub G1 phase and G1 phase phase. SU056 (0-1 μ M, 12 hours) inhibits migration of OVCAR8, SKOV3 and ID8 cells. SU056 (0-5 μ M, 24 hours) induce apoptosis of OVCAR8, SKOV3, and ID8 cells. SU056 (1-5 μ M, 12 h) inhibits the expression of YB-1, TMSB10, SUMO2, and PMSB2 proteins in OVCAR8 cells. SU056 (0.1, 0.5, and 1 μ M. 48 hours) enhances the cytotoxic effect of paclitaxel (0.1, 0.5, and 1 nM) [1].
In vivo	SU056 (20 mg/kg, intraperitoneal injection) inhibits tumor growth in mice implanted with ID8 cells. SU056 (10 mg/kg, intraperitoneal injection, daily) combined with paclitaxel (5 mg/kg, weekly, intraperitoneal injection) inhibits tumor growth in immunodeficient mice implanted with ovarian cancer cells (OVCAR8), and the effect is more significant than that of single administration [1].

Chemical Properties

Molecular Weight	369.34
Formula	C₂₀H₁₆FNO₅
Cas No.	2376580-08-2
Smiles	OCCN1C2=C(C(c3cccc(F)c3)c3cc4OCOc4cc13)C(=O)OC2
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (203.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7075 mL	13.5377 mL	27.0753 mL	135.3766 mL
5 mM	0.5415 mL	2.7075 mL	5.4151 mL	27.0753 mL
10 mM	0.2708 mL	1.3538 mL	2.7075 mL	13.5377 mL
20 mM	0.1354 mL	0.6769 mL	1.3538 mL	6.7688 mL
50 mM	0.0542 mL	0.2708 mL	0.5415 mL	2.7075 mL
100 mM	0.0271 mL	0.1354 mL	0.2708 mL	1.3538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc