CDK6 Protein, Human, Recombinant (His)

Name: CDK6 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPC-00161
Rating: 4.5 (1 reviews)

(Synonyms: Serine/threonine-protein kinase PLSTIRE, Cyclin-dependent kinase 6, CDKN6, CDK6) Copy Product Info

Synonyms: Serine/threonine-protein kinase PLSTIRE, Cyclin-dependent kinase 6, CDKN6, CDK6

Catalog No. TMPC-00161 Copy Product Info

CDK6 Protein, Human, Recombinant (His) is expressed in Baculovirus-Insect Cells. The accession number is Q00534.

Pack Size	Price	USA Stock	Global Stock	Quantity
20 µg	$953	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	CDK6 Protein, Human, Recombinant (His) is expressed in Baculovirus-Insect Cells. The accession number is Q00534.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-His
Accession Number	Q00534
Construction	Recombinant full length human CDK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Protein Purity	>90% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Synonyms	Serine/threonine-protein kinase PLSTIRE, Cyclin-dependent kinase 6, CDKN6, CDK6
Research Background	The cell-cycle kinase CDK6 has been recognized not only as a typical cyclin-dependent kinase but as a transcriptional regulator with properties distinct from those of its close homologue CDK4. CDK6 regulates the transcription of a number of genes and its effects may be dependent on or independent of its kinase activity. The transcriptional function of CDK6 is crucial for its role in promoting myeloid and lymphoid malignancies, including AML and ALL and is important in maintaining hematopoietic and leukemic stem cells. CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific manner. In early stages CDK6 kinase induces a complex transcriptional program to block p53 in hematopoietic cells. Cells lacking CDK6 kinase function are required to mutate p53 to achieve a fully transformed immortalized state. CDK6 binds to the promoters of genes including the p53-antagonists PRMT5, PPM1D and MDM4.

Chemical Properties

Molecular Weight

~39 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.