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TargetMol | Compound Library

Immunology/Inflammation Compound Library

Catalog No. L4700

An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Areas often affected by autoimmune disorders include blood vessels, connective tissues, joints, and skin, etc. The chemical advances in the 19th–20th centuries brought about the development of non-steroidal anti-inflammatory drugs (NSAIDs). Although effective in the treatment of inflammatory diseases, NSAIDs have some undesirable and adverse effect, such as ulcers, kidney injury, and bleeding in the gastrointestinal tract. Although initially identified as anti-tumor molecule, TNF is now considered as a pleiotropic cytokine which plays a major role in immune or inflammatory responses. Consequently, anti-TNF biologics, which are designed to block the biological function of TNF, have been developed for the therapy of autoimmune inflammatory diseases. The success of biologics for autoimmune diseases coupled with rapid advances in basic research has validated many immunology-relevant signaling pathways and uncovered new intracellular molecules to target for potential new drug agents that can enter the cell. For example, many small chemicals or macrolide derivatives that can inhibit immunoproteasome, nucleus output proteins, NF-kB, and TNF-alpha have the potential to be developed as the drugs to treat the autoimmune inflammatory diseases and chronic inflammatory diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L4700

Immunology/Inflammation Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 5293 anti-inflammation compounds effective for high throughput screening and high content screening.
  • Bioactivity and safety confirmed by clinical research and trials, some of which are FDA approved;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

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  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Composition

Apoptosis
Antibacterial
Autophagy
Antibiotic
COX
NF-κB
Endogenous Metabolite
PI3K
Histamine Receptor
EGFR
Reactive Oxygen Species
HIV Protease
Parasite
Prostaglandin Receptor
JAK
Antifungal
Antiviral
p38 MAPK
mTOR
IL Receptor
TNF
ERK
Akt
STAT
Antioxidant
NO Synthase
ROS
5-HT Receptor
AMPK
TLR
GSK-3
Influenza Virus
Raf
CDK
DNA/RNA Synthesis
AChR
Adrenergic Receptor
Nrf2
Potassium Channel
PDE
Cytochromes P450
NOS
MAPK
Ras
CCR
JNK
Calcium Channel
PPAR
Glucocorticoid Receptor
SARS-CoV
IκB/IKK
HCV Protease
Immunology/Inflammation related
Interleukin
Ferroptosis
VEGFR
Lipoxygenase
CXCR
MEK
Dehydrogenase
FLT
Virus Protease
MMP
Src
Dopamine Receptor
Tyrosine Kinases
NOD
Caspase
DNA-PK
PKC
RIP kinase
Reverse Transcriptase
HBV
Wnt/beta-catenin
Topoisomerase
GPCR
S6 Kinase
HSV
GABA Receptor
TRP/TRPV Channel
Antifection
Cholinesterase (ChE)
ATM/ATR
HER
Mitophagy
LTR
PDGFR
Beta Amyloid
Estrogen/progestogen Receptor
Phosphatase
Pim
Aryl Hydrocarbon Receptor
Bcl-2 Family
Syk
Sodium Channel
ribosome
Phospholipase
FGFR
AhR
Epigenetic Reader Domain
TGF-beta/Smad
STING
PDK
Complement System
IRAK
PD-1/PD-L1
Adenosine Receptor
MRP
Cannabinoid Receptor
Casein Kinase
S1P Receptor
PKA
Mitochondrial Metabolism
HDAC
HIF/HIF Prolyl-Hydroxylase
RAAS
c-Kit
Microtubule Associated
LPL Receptor
Proteasome
ATPase
Rho
Opioid Receptor
Aurora Kinase
Integrin
PARP
MAO
PGE Synthase
Anti-infection
Tyrosinase
NOD-like Receptor (NLR)
Kras
Histone Methyltransferase
NADPH
Estrogen Receptor/ERR
Serine Protease
Bcr-Abl
Drug Metabolite
IGF-1R
Norepinephrine
Sirtuin
PI4K
P-gp
NADPH-oxidase
ALK
c-RET
c-Met/HGFR
P2X Receptor
HSP
c-Fms
Thrombin
BTK
P2Y Receptor
IFNAR
Leukotriene Receptor
ROCK
MNK
HIF
p53
Proton pump
Carbonic Anhydrase
Glutathione Peroxidase
Nucleoside Antimetabolite/Analog
FAAH
Indoleamine 2,3-Dioxygenase (IDO)
ROS Kinase
Arginase
Trk receptor
MLK
Cysteine Protease
SIK
E1/E2/E3 Enzyme
Chk
Xanthine Oxidase
GluR
CaMK
DNA
transporter
Retinoid Receptor
Sigma receptor
FAK
Chloride channel
ROR
MyD88
Reductase
GTPase
Antifolate
Serotonin Transporter
DNA gyrase
Glucosidase
PTEN
DUB
Free radical scavengers
Aminopeptidase
ASK
Transferase
MALT
DYRK
Histone Demethylase
PERK
Progesterone Receptor
c-Myc
FXR
iGluR
FLAP
Gamma-secretase
NMDAR
Fatty Acid Synthase
Hedgehog/Smoothened
Epoxide Hydrolase
cAMP
cGAS
Pyroptosis
MELK
RSV
Ligand for E3 Ligase
Platelet aggregation
Protease-activated Receptor
PROTACs
DHFR
BACE
Cell wall
Galectin
Cholecystokinin Receptor
Serine/threonin kinase
CSF-1R
UGT
LDL
Monoamine Transporter
Guanylate cyclase
DPP-4
Bradykinin Receptor
Telomerase
CD73
Histone Acetyltransferase
LPA Receptor
SGK
HMG-CoA Reductase
CD38
ADC Cytotoxin
Amino Acids and Derivatives
Lipase
gp120/CD4
TOPK
IDO
Annexin A
ABC Transporter
Thrombopoietin Receptor
Androgen Receptor
SGLT
Acyltransferase
AIM2
Decarboxylase
PAI-1
Melanocortin Receptor
PLK
Neurokinin receptor
Monoamine Oxidase
Adenylyl Cyclase
RAR/RXR
Factor Xa
Liver X Receptor
RANKL/RANK
IAP
PAFR
Molecular Glues
Smo
PAK
Somatostatin
Lipid
GPCR19
Ephrin Receptor
Acetyl-CoA Carboxylase
Aromatase
KLF
CRISPR/Cas9
Adenosine Deaminase
Discoidin Domain Receptor (DDR)
DNA Methyltransferase
PKM
Thyroid hormone receptor(THR)
Advanced Glycation End Products
Mdm2
MicroRNA
NPC1L1
EBI2/GPR183
Dynamin
DNA Alkylator/Crosslinker
Arrestin
Tie-2
Melatonin Receptor
GNRH Receptor
Cell Cycle Arrest
Glucokinase
PYK2
Glutaminase
Integrase
DNA Alkylation
ACK1
Endothelin Receptor
ATP Citrate Lyase
BCRP
Beta-Secretase
Glutathione reductase
OAT
LRRK2
Hippo pathway
FKBP
GPX
Oxytocin Receptor
Hydroxylase
DAPK
Gap Junction Protein
Imidazoline Receptor
IKZF
FOXO3
Melanin-concentrating Hormone Receptor (MCHR)
Apelin receptor
Taste receptor
GSNOR
Monocarboxylate transporter
stilbene oxidase
Hydrogenase
CRM1
Ligands for Target Protein for PROTAC
YAP
Na+/Ca2+ Exchanger
Necroptosis
VDA
OCT
N-Acetylglucosaminyltransferase
CaSR
AAK1
Neurotensin Receptor
LIM Kinase
Amylase
Myosin
Adiponectin Receptor
Haspin Kinase
PACAP
MT Receptor
Glucagon Receptor
GlyT
Na-K-Cl cotransporter
Anion Exchanger
PROTAC Linker
Neuropeptide Y Receptor
MAGL
Bombesin Receptor
Vasopressin Receptor
Angiotensin-converting Enzyme (ACE)
OX Receptor
OXPHOS
Survivin
MRGPR
GluCls
hCE
CRFR
Methionine Adenosyltransferase (MAT)
Neprilysin
GST
Protease
GHSR
RXFP receptor
CGRP Receptor
BMI-1
TAM Receptor
CFTR
Kinesin
Vitamin