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Immunology/Inflammation Compound Library

Catalog No. L4700
  Library Compound List   Excel SDF

An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Areas often affected by autoimmune disorders include blood vessels, connective tissues, joints, and skin, etc. The chemical advances in the 19th–20th centuries brought about the development of non-steroidal anti-inflammatory drugs (NSAIDs). Although effective in the treatment of inflammatory diseases, NSAIDs have some undesirable and adverse effect, such as ulcers, kidney injury, and bleeding in the gastrointestinal tract. Although initially identified as anti-tumor molecule, TNF is now considered as a pleiotropic cytokine which plays a major role in immune or inflammatory responses. Consequently, anti-TNF biologics, which are designed to block the biological function of TNF, have been developed for the therapy of autoimmune inflammatory diseases. The success of biologics for autoimmune diseases coupled with rapid advances in basic research has validated many immunology-relevant signaling pathways and uncovered new intracellular molecules to target for potential new drug agents that can enter the cell. For example, many small chemicals or macrolide derivatives that can inhibit immunoproteasome, nucleus output proteins, NF-kB, and TNF-alpha have the potential to be developed as the drugs to treat the autoimmune inflammatory diseases and chronic inflammatory diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.
  • Bioactivity and safety confirmed by clinical research and trials, some of which are FDA approved;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L4700)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
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Library Composition

Antibacterial (495)
Apoptosis (403)
Antibiotic (398)
Autophagy (347)
Endogenous Metabolite (273)
COX (246)
Reactive Oxygen Species (159)
NF-κB (158)
Histamine Receptor (139)
HIV Protease (125)
Parasite (124)
Antifungal (123)
EGFR (84)
Prostaglandin Receptor (78)
Influenza Virus (78)
DNA/RNA Synthesis (77)
IL Receptor (69)
TNF (67)
5-HT Receptor (66)
JAK (65)
NO Synthase (64)
p38 MAPK (57)
Adrenergic Receptor (56)
STAT (56)
HDAC (56)
Antioxidant (56)
AChR (56)
P450 (53)
ROS (52)
TLR (51)
Glucocorticoid Receptor (46)
Ferroptosis (45)
HCV Protease (43)
Virus Protease (43)
Interleukin (43)
SARS-CoV (42)
PPAR (42)
PDE (40)
Antiviral (39)
Dehydrogenase (39)
Nrf2 (39)
Potassium Channel (37)
NOS (37)
Topoisomerase (36)
CXCR (35)
HSV (34)
Reverse Transcriptase (33)
PI3K (33)
HBV (33)
ERK (32)
Calcium Channel (32)
Mitophagy (31)
ribosome (30)
CCR (30)
Lipoxygenase (29)
Dopamine Receptor (29)
IκB/IKK (28)
Estrogen/progestogen Receptor (27)
AMPK (26)
MMP (26)
Sodium Channel (25)
Caspase (24)
Akt (24)
VEGFR (24)
Aryl Hydrocarbon Receptor (23)
AChE (23)
HER (23)
Antifection (23)
Tyrosine Kinases (23)
GABA Receptor (22)
Phospholipase (22)
Immunology/Inflammation related (21)
Src (21)
TRP/TRPV Channel (20)
JNK (20)
FLT (20)
NOD (20)
HIF/HIF Prolyl-Hydroxylase (20)
Estrogen Receptor/ERR (20)
CDK (19)
Phosphatase (19)
Adenosine Receptor (19)
Microtubule Associated (19)
Epigenetic Reader Domain (19)
PKC (19)
Proteasome (19)
AhR (18)
Complement System (17)
STING (17)
MRP (17)
GPR (17)
ATPase (16)
FGFR (16)
Nucleoside Antimetabolite/Analog (16)
NOD-like Receptor (NLR) (15)
BCL (15)
Tyrosinase (15)
Wnt/beta-catenin (15)
BTK (15)
Anti-infection (15)
IRAK (14)
TGF-beta/Smad (14)
Syk (14)
Mitochondrial Metabolism (14)
Indoleamine 2,3-Dioxygenase (IDO) (14)
Beta Amyloid (14)
PGE Synthase (14)
RAAS (14)
Norepinephrine (14)
Retinoid Receptor (13)
NADPH (13)
S1P Receptor (12)
Sirtuin (12)
MAPK (12)
Opioid Receptor (12)
MAO (12)
PARP (12)
Serine Protease (12)
Cannabinoid Receptor (12)
PD-1/PD-L1 (11)
LTR (11)
mTOR (11)
P-gp (11)
Thrombin (11)
HSP (11)
PDGFR (11)
LPL Receptor (11)
Proton pump (11)
Carbonic Anhydrase (10)
Leukotriene Receptor (10)
IFNAR (10)
DNA gyrase (10)
ALK (10)
Antifolate (10)
p53 (10)
Drug Metabolite (9)
c-Kit (9)
Integrin (9)
Histone Methyltransferase (9)
MEK (9)
Pim (9)
Cysteine Protease (9)
DHFR (9)
ROS Kinase (9)
DNA (8)
Gamma-secretase (8)
Chloride channel (8)
RIP kinase (8)
c-Fms (8)
HIF (8)
CAT (7)
ROR (7)
Monoamine Oxidase (7)
Arginase (7)
IGF-1R (7)
S6 Kinase (7)
Xanthine Oxidase (7)
Glutathione Peroxidase (7)
Ligand for E3 Ligase (7)
Trk receptor (7)
c-Met/HGFR (6)
FXR (6)
iGluR (6)
Serotonin Transporter (6)
FAAH (6)
NADPH-oxidase (6)
Bcr-Abl (6)
PKA (6)
Raf (6)
GSK-3 (6)
Ras (6)
cGAS (5)
Epoxide Hydrolase (5)
Casein Kinase (5)
Aurora Kinase (5)
ATM/ATR (5)
c-RET (5)
Sigma receptor (5)
CaMK (5)
transporter (5)
Free radical scavengers (5)
Aminopeptidase (5)
Androgen Receptor (5)
RSV (5)
Thyroid hormone receptor(THR) (5)
P2X Receptor (5)
Cell wall (5)
DNA Alkylator/Crosslinker (5)
Serine/threonin kinase (5)
ROCK (5)
IDO (5)
Reductase (5)
Progesterone Receptor (5)
NMDAR (5)
Amino Acids and Derivatives (5)
E1/E2/E3 Enzyme (5)
Hedgehog/Smoothened (5)
UGT (5)
P2Y Receptor (4)
Platelet aggregation (4)
FLAP (4)
Annexin A (4)
SIK (4)
CSF-1R (4)
LPA Receptor (4)
Liver X Receptor (4)
DNA Methyltransferase (4)
Fatty Acid Synthase (4)
Telomerase (4)
DUB (4)
DNA-PK (4)
GluR (4)
Protease-activated Receptor (4)
TAM Receptor (4)
FAK (4)
MyD88 (4)
HMG-CoA Reductase (4)
CFTR (4)
Transferase (4)
Aromatase (3)
PAFR (3)
c-Myc (3)
MALT (3)
Decarboxylase (3)
Histone Acetyltransferase (3)
Thrombopoietin Receptor (3)
CD73 (3)
Bradykinin Receptor (3)
Molecular Glues (3)
Pyroptosis (3)
Hydroxylase (3)
Glutathione reductase (3)
Acetyl-CoA Carboxylase (3)
Glucosidase (3)
Lipase (3)
DPP-4 (3)
Histone Demethylase (3)
Neurokinin receptor (3)
cholecystokinin (3)
BACE (3)
Discoidin Domain Receptor (DDR) (2)
Dynamin (2)
Adenosine deaminase (2)
Gap Junction Protein (2)
Rho (2)
cell cycle arrest (2)
Imidazoline Receptor (2)
DprE1 (2)
YAP (2)
Galectin (2)
CRISPR/Cas9 (2)
ABC (2)
PDK (2)
GTPase (2)
Melatonin Receptor (2)
DYRK (2)
RAR/RXR  (2)
Factor Xa (2)
EBI2/GPR183 (2)
VDA (2)
gp120/CD4 (2)
Glucokinase (2)
Chk (2)
GST (2)
PAD (2)
advanced glycation end products (2)
Monoamine Transporter (2)
Endothelin Receptor (2)
IAP (2)
GluCls (2)
Integrase (2)
PAI-1 (2)
Smo (2)
PTEN (2)
OAT (2)
Acyltransferase (2)
Guanylate cyclase (2)
ATP Citrate Lyase (2)
Hippo pathway (2)
PAK (2)
Bombesin Receptor (1)
Anion Exchanger (1)
Isocitrate Dehydrogenase (IDH) (1)
SGLT (1)
CRM1 (1)
Lipid (1)
PROTAC Linker (1)
CD38 (1)
DNA Alkylation (1)
cAMP (1)
Vasopressin Receptor (1)
Hydrogenase (1)
stilbene oxidase (1)
Monocarboxylate transporter (1)
NPC1L1 (1)
OX Receptor (1)
MLK (1)
GSNOR (1)
Adenylyl cyclase (1)
PKM (1)
Taste receptor (1)
Mdm2 (1)
Na+/Ca2+ Exchanger (1)
Somatostatin (1)
Hexokinase (1)
GPCR19 (1)
Neprilysin (1)
Hck (1)
FOXO1 (1)
GNRH Receptor (1)
N-Acetylglucosaminyltransferase (1)
Methionine Adenosyltransferase (MAT) (1)
Amylase (1)
CaSR (1)
PI4K (1)
Melanocortin Receptor (1)
hCE (1)
ASK (1)
IRE1 (1)
Ephrin Receptor (1)
Adiponectin receptor (1)
BCRP (1)
LRRK2 (1)
MTH1 (1)
PLK (1)
Haspin Kinase (1)
TOPK (1)
Tie-2 (1)
LDL (1)
MT Receptor (1)
PERK (1)
Phosphorylase (1)
MNK (1)
Survivin (1)
GlyT (1)
RANKL/RANK (1)
OXPHOS (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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