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2-Bromo-4'-hydroxyacetophenone

🥰Excellent
Catalog No. T7084Cas No. 2491-38-5
Alias α-Bromo-4-hydroxyacetophenone, SHP-1 Inhibitor II, PTP Inhibitor I, 4-Hydroxyphenacyl bromide

2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].

2-Bromo-4'-hydroxyacetophenone

2-Bromo-4'-hydroxyacetophenone

🥰Excellent
Purity: 98.64%
Catalog No. T7084Alias α-Bromo-4-hydroxyacetophenone, SHP-1 Inhibitor II, PTP Inhibitor I, 4-Hydroxyphenacyl bromideCas No. 2491-38-5
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].
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1 g$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.64%
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Product Introduction

Bioactivity
Description
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].
Targets&IC50
SHP1:43 μM (Ki, cell free), PTP1B:42 μM (Ki, cell free)
Cell Research
Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis.
Synonymsα-Bromo-4-hydroxyacetophenone, SHP-1 Inhibitor II, PTP Inhibitor I, 4-Hydroxyphenacyl bromide
Chemical Properties
Molecular Weight215.04
FormulaC8H7BrO2
Cas No.2491-38-5
SmilesOC1=CC=C(C=C1)C(=O)CBr
Relative Density.1.622 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 20 mg/mL (93.01 mM), Sonication is recommended.
H2O: Insoluble
DMSO: 60 mg/mL (279.02 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.3 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.6503 mL23.2515 mL46.5030 mL232.5149 mL
5 mM0.9301 mL4.6503 mL9.3006 mL46.5030 mL
10 mM0.4650 mL2.3251 mL4.6503 mL23.2515 mL
20 mM0.2325 mL1.1626 mL2.3251 mL11.6257 mL
50 mM0.0930 mL0.4650 mL0.9301 mL4.6503 mL
DMSO
1mg5mg10mg50mg
100 mM0.0465 mL0.2325 mL0.4650 mL2.3251 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

protein tyrosine phosphatase(PTP)PhosphataseInhibitorinhibitalpha-Bromo-4-hydroxyacetophenonea-Bromo-4-hydroxyacetophenone4-Hydroxyphenacyl Bromide2Bromo4'hydroxyacetophenone2-Bromo-4'-hydroxyacetophenone2 Bromo 4' hydroxyacetophenone
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