Valategrast hydrochloride

Name: Valategrast hydrochloride
Brand: TargetMol
SKU: T29089
Rating: 4.5 (1 reviews)

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Catalog No. T29089Cas No. 828271-96-1

Alias Valategrast HCl, RO-27-2441, RO27244, RO-0272441, RO0272441, R-411, R411

Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.

Valategrast hydrochloride

😃Good

Catalog No. T29089Alias Valategrast HCl, RO-27-2441, RO27244, RO-0272441, RO0272441, R-411, R411Cas No. 828271-96-1

Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.

Pack Size	Price	Availability
25 mg	$1,670	6-8 weeks
50 mg	$2,180	6-8 weeks
100 mg	$2,800	6-8 weeks

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Product Introduction

Bioactivity

Description	Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
In vitro	Valategrast hydrochloride incorporates a prevalent l-phenylalanine-N-aroyl structure, with the carboxylic acid moiety facilitating attachment to the metal ion at the metal-ion-dependent adhesion site (MIDAS)[2].
Synonyms	Valategrast HCl, RO-27-2441, RO27244, RO-0272441, RO0272441, R-411, R411

Chemical Properties

Molecular Weight	641.41
Formula	C₃₀H₃₃Cl₄N₃O₄
Cas No.	828271-96-1
Smiles	C(N[C@@H](CC1=CC=C(NC(=O)C2=C(Cl)C=CC=C2Cl)C=C1)C(OCCN(CC)CC)=O)(=O)C3=C(C)C=CC=C3Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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