HRG/HPRG Protein, Mouse, Recombinant (His)

Name: HRG/HPRG Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-07234
Rating: 4.5 (1 reviews)

(Synonyms: Hrgp, Hrg, Hprg, D18020, D16jh2) Copy Product Info

Synonyms: Hrgp, Hrg, Hprg, D18020, D16jh2

Catalog No. TMPY-07234 Copy Product Info

HRG/HPRG Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9ESB3.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$109	7-10 days	7-10 days
20 µg	$172	7-10 days	7-10 days
50 µg	$343	7-10 days	7-10 days
100 µg	$682	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days
500 µg	$2,200	7-10 days	7-10 days
1 mg	$4,500	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	HRG/HPRG Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9ESB3.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q9ESB3
Construction	A DNA sequence encoding the Mouse HRG (Q9ESB3) (Leu19-Lys525) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity	≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Please refer to the lot-specific COA.
Synonyms	Hrgp, Hrg, Hprg, D18020, D16jh2
Research Background	Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

Chemical Properties

Molecular Weight

58.69 kDa (predicted); 80.7 kDa (reducing contition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.