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Anti-E-Selectin/CD62E Antibody (5O468)
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Catalog No. TMAY-00642
Alias selectin E, LECAM2, ESEL, ELAM1, ELAM, CD62E
Anti-E-Selectin/CD62E Antibody (5O468) is a Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody (5O468) can be used in ICC/IF.
Anti-E-Selectin/CD62E Antibody (5O468)
Anti-E-Selectin/CD62E Antibody (5O468)
😃Good
Catalog No. TMAY-00642Alias selectin E, LECAM2, ESEL, ELAM1, ELAM, CD62E
Anti-E-Selectin/CD62E Antibody (5O468) is a Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody (5O468) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-E-Selectin/CD62E Antibody (5O468) is a Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody (5O468) can be used in ICC/IF. |
| Alias | selectin E, LECAM2, ESEL, ELAM1, ELAM, CD62E |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5O468 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of CD62E in TNF-a stimulated HUVEC cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-human ABHD14B monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cells membrane. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human E-Selectin / CD62e / SELE (rh E-Selectin / CD62e / SELE; TMPY-01167; NP_000441.2; Met1-Pro556). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. Besides, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human E-Selectin / CD62e / SELE Protein (TMPY-01167) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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