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Picrotoxinin

🥰Excellent
Catalog No. T16535Cas No. 17617-45-7

Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.

Picrotoxinin

Picrotoxinin

🥰Excellent
Purity: 98.07%
Catalog No. T16535Cas No. 17617-45-7
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$48In Stock-
25 mg$98In Stock-
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.07%
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Product Introduction

Bioactivity
Description
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
In vitro
Picrotoxinin (1 nM-1 mM) dose-dependently inhibits the action of the GABAA receptor and inhibits etomidate, propofol, diazepam, thiopentone sodium, loreclezole and allopregnanolone with IC50s of 0.55 μM, 0.49 μM, 0.35 μM, 0.50 μM, 0.14 μM and 0.44 μM in the presence of EC5 GABA, respectively[1].
Chemical Properties
Molecular Weight292.28
FormulaC15H16O6
Cas No.17617-45-7
Smiles[H][C@@]12C[C@@]3(O)[C@]4([H])[C@H](C(C)=C)[C@@]([H])(OC4=O)[C@@]4([H])OC(=O)[C@]1(O2)[C@@]34C
Relative Density.1.2207 g/cm3 (Estimated)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90.0 mg/mL (307.9 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.29 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4214 mL17.1069 mL34.2138 mL171.0688 mL
5 mM0.6843 mL3.4214 mL6.8428 mL34.2138 mL
10 mM0.3421 mL1.7107 mL3.4214 mL17.1069 mL
20 mM0.1711 mL0.8553 mL1.7107 mL8.5534 mL
50 mM0.0684 mL0.3421 mL0.6843 mL3.4214 mL
100 mM0.0342 mL0.1711 mL0.3421 mL1.7107 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PicrotoxininGABAReceptorGABAAGABA ReceptorChloridechannelchloride channelChloride channel
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