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Picrotoxinin

Name: Picrotoxinin
Brand: TargetMol
SKU: T16535
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T16535 Copy Product Info

Purity: 99.81%

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Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.

Picrotoxinin

Copy Product Info

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Catalog No. T16535

Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.

Cas No. 17617-45-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$48	In Stock	In Stock
25 mg	$98	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
In vitro	Picrotoxinin (1 nM-1 mM) dose-dependently inhibits the action of the GABAA receptor and inhibits etomidate, propofol, diazepam, thiopentone sodium, loreclezole and allopregnanolone with IC50s of 0.55 μM, 0.49 μM, 0.35 μM, 0.50 μM, 0.14 μM and 0.44 μM in the presence of EC5 GABA, respectively[1].

Chemical Properties

Molecular Weight	292.28
Formula	C₁₅H₁₆O₆
Cas No.	17617-45-7
Smiles	[H][C@@]12C[C@@]3(O)[C@]4([H])[C@H](C(C)=C)[C@@]([H])(OC4=O)[C@@]4([H])OC(=O)[C@]1(O2)[C@@]34C
Relative Density.	1.2207 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (307.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4214 mL	17.1069 mL	34.2138 mL	171.0688 mL
5 mM	0.6843 mL	3.4214 mL	6.8428 mL	34.2138 mL
10 mM	0.3421 mL	1.7107 mL	3.4214 mL	17.1069 mL
20 mM	0.1711 mL	0.8553 mL	1.7107 mL	8.5534 mL
50 mM	0.0684 mL	0.3421 mL	0.6843 mL	3.4214 mL
100 mM	0.0342 mL	0.1711 mL	0.3421 mL	1.7107 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc