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PGE Synthase

Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.The synthase generating PGE2 is a membrane-associated protein.

  • (S)-Flurbiprofen
    T5843L51543-39-6
    Esflurbiprofen is an inhibitor of COX-1 and COX-2.
    • $29
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  • ETHYL CAFFEATE
    T5681102-37-4
    Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related signaling, including IFN-γ, T-bet, STAT1, and STAT4.
    • $41
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    TargetMol | Citations Cited
  • hPGDS-IN-1
    T26811234708-04-3
    hPGDS-IN-1 is a hPGDS inhibitor.
    • $73
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    TargetMol | Inhibitor Sale
  • Limaprost
    T1575774397-12-9
    Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.
    • $198
    35 days
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    TargetMol | Inhibitor Sale
  • HPGDS inhibitor 2
    T79482101626-26-8
    HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm.
    • $88
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  • AT-56
    T1866162640-98-4
    AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.
    • $33
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  • HPGDS inhibitor 1
    T18041033836-12-2
    HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.
    • $88
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    TargetMol | Inhibitor Sale
  • Pranoprofen
    T015952549-17-4
    Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
    • $42
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  • CAFESTOL
    T5727469-83-0
    CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
    • $32
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  • Friluglanstat
    T798461422203-86-8
    Friluglanstat is an inhibitor of the enzyme prostaglandin E synthase (mPGES-1) and exhibits anti-inflammatory activity [1].
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  • Sinensetin
    T4S02272306-27-6
    Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
    • $57
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  • Suprofen
    T668740828-46-4
    Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
    • $35
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  • F092
    T697302250261-59-5
    F092 is a potent inhibitor of hematopoietic prostaglandin D synthetase (H-PGDS), which can be used to study allergic inflammation and vascular-related diseases.
    • $56
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  • Dehydroevodiamine
    T2S233567909-49-3
    Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.
    • $35
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  • Benzydamine hydrochloride
    T0726132-69-4
    Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
    • $33
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  • Zomepirac sodium salt
    T026464092-48-4
    Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.
    • $31
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  • Bismuth Subsalicylate
    T042414882-18-9
    Bismuth Subsalicylate (Bismuth subsalicylat) is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
    • $48
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