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NL-1

Name: NL-1
Brand: TargetMol
SKU: T8308
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8308Cas No. 188532-26-5

NL-1, a mitoNEET inhibitor, exhibits antileukemic effects.

NL-1

🥰Excellent

Purity: 98.64%

Catalog No. T8308Cas No. 188532-26-5

NL-1, a mitoNEET inhibitor, exhibits antileukemic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$61	In Stock	In Stock
25 mg	$126	In Stock	In Stock
50 mg	$216	In Stock	In Stock
100 mg	$324	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.64%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NL-1, a mitoNEET inhibitor, exhibits antileukemic effects.
In vitro	NL-1 Reduced the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner.
In vivo	NL-1 showed antileukemic activity in an in vivo mouse ALL model
Cell Research	Cell Line:REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines. Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 100 μM.Incubation Time:72 hours
Animal Research	Animal Model:10 female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells. Dosage:10 mg/kg.Administration:Intraperitoneal injection; daily; for 5 days

Chemical Properties

Molecular Weight	335.46
Formula	C₁₈H₂₅NO₃S
Cas No.	188532-26-5
Smiles	CC(C)(C)c1cc(CC2SC(=O)NC2=O)cc(c1O)C(C)(C)C
Relative Density.	1.167 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (745.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9810 mL	14.9049 mL	29.8098 mL	149.0491 mL
5 mM	0.5962 mL	2.9810 mL	5.9620 mL	29.8098 mL
10 mM	0.2981 mL	1.4905 mL	2.9810 mL	14.9049 mL
20 mM	0.1490 mL	0.7452 mL	1.4905 mL	7.4525 mL
50 mM	0.0596 mL	0.2981 mL	0.5962 mL	2.9810 mL
100 mM	0.0298 mL	0.1490 mL	0.2981 mL	1.4905 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc