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CD73-IN-4

Name: CD73-IN-4
Brand: TargetMol
SKU: T9210
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9210Cas No. 2216764-29-1

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

CD73-IN-4

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Purity: 98.61%

Catalog No. T9210Cas No. 2216764-29-1

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$255	In Stock	In Stock
10 mg	$413	In Stock	In Stock
25 mg	$738	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,390	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$258	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.61%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

CD73-IN-4 AI Summary

CD73-IN-4 shows potent inhibitory bioactivity on human C-terminal His6-tagged CD73, with an IC50 value of 11.0 nM. It exhibits significant inhibition of CD73 in human SK-OV-3 cells, human CD73 in CHO cells, soluble human CD73, and soluble mouse CD73, with IC50 values ranging from 0.55 nM to 3.0 nM. Compared to these, its inhibitory activity against human CD39 and mouse CD73 expressed in CHO cells is substantially weaker, with IC50 values exceeding 10,000.0 nM. The compound also demonstrates poor inhibition against A2AR and various NTPDase enzymes. Pharmacokinetically, CD73-IN-4 shows moderate clearance and a relatively short half-life in Sprague-Dawley rats. These data suggest that CD73-IN-4 holds promise as a selective CD73 inhibitor but may have limited effects on other purinergic enzymes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.
Targets&IC50	CD73:2.6 nM

Chemical Properties

Molecular Weight	463.81
Formula	C₁₆H₂₃ClN₅O₇P
Cas No.	2216764-29-1
Smiles	O[C@H]1[C@H](N2C=3C(C=N2)=C(NC4CCCC4)N=C(Cl)N3)O[C@H](COCP(=O)(O)O)[C@H]1O
Relative Density.	1.97 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (269.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1561 mL	10.7803 mL	21.5606 mL	107.8028 mL
5 mM	0.4312 mL	2.1561 mL	4.3121 mL	21.5606 mL
10 mM	0.2156 mL	1.0780 mL	2.1561 mL	10.7803 mL
20 mM	0.1078 mL	0.5390 mL	1.0780 mL	5.3901 mL
50 mM	0.0431 mL	0.2156 mL	0.4312 mL	2.1561 mL
100 mM	0.0216 mL	0.1078 mL	0.2156 mL	1.0780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc