Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 96.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 396.00 | |
25 mg | In stock | $ 689.00 | |
50 mg | In stock | $ 979.00 | |
100 mg | In stock | $ 1,320.00 | |
500 mg | In stock | $ 2,650.00 |
Description | Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60. |
In vitro | Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin mutant HCT116 cells and isogenic HCT116 cells (CTNNB1 Δ45/-), and (10 μM; 24 h) induces apoptosis in HCT116 cells.[1] |
Synonyms | DS37262926 |
Molecular Weight | 441.52 |
Formula | C26H27N5O2 |
CAS No. | 2494198-61-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (113.25 mM)
You can also refer to dose conversion for different animals. More
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Miclxin 2494198-61-5 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin DS 37262926 DS-37262926 DS37262926 inhibitor inhibit