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PD-118057

Name: PD-118057
Brand: TargetMol
SKU: T16444
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16444Cas No. 313674-97-4

PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.

PD-118057

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Purity: 99.97%

Catalog No. T16444Cas No. 313674-97-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$76	In Stock	In Stock
2 mg	$109	In Stock	In Stock
5 mg	$185	In Stock	In Stock
10 mg	$276	In Stock	In Stock
25 mg	$488	In Stock	In Stock
50 mg	$728	In Stock	In Stock
100 mg	$1,090	In Stock	In Stock
200 mg	$1,470	-	In Stock
1 mL x 10 mM (in DMSO)	$203	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.
In vitro	PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in acutely isolated guinea pig ventricular cardiomyocytes.[1][2] At 10 μM, PD-118057 counteracts the current inhibition caused by Dof and Mox, preserves the unaltered 'hump' shape of the IKr current, and shows only a marginal increase in the maximum value of the suppressed current.[2]

Chemical Properties

Molecular Weight	386.27
Formula	C₂₁H₁₇Cl₂NO₂
Cas No.	313674-97-4
Smiles	OC(=O)c1ccccc1Nc1ccc(CCc2ccc(Cl)c(Cl)c2)cc1
Relative Density.	1.353 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (233 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5889 mL	12.9443 mL	25.8886 mL	129.4431 mL
5 mM	0.5178 mL	2.5889 mL	5.1777 mL	25.8886 mL
10 mM	0.2589 mL	1.2944 mL	2.5889 mL	12.9443 mL
20 mM	0.1294 mL	0.6472 mL	1.2944 mL	6.4722 mL
50 mM	0.0518 mL	0.2589 mL	0.5178 mL	2.5889 mL
100 mM	0.0259 mL	0.1294 mL	0.2589 mL	1.2944 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc