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Pentiapine

Name: Pentiapine
Brand: TargetMol
SKU: T12405
Price: 513 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: CGS 10746) Copy Product Info

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Synonyms: CGS 10746

Catalog No. T12405 Copy Product Info

Purity: 99.35%

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Pentiapine (CGS 10746) is a small-molecule inhibitor and a dopamine release inhibitor with cell permeability, used in neuropharmacological research to modulate dopaminergic signaling, holding significant application value in studies related to nervous system mechanisms.

Cas No. 81382-51-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$513	In Stock	In Stock
5 mg	$793	In Stock	In Stock
10 mg	$1,280	In Stock	In Stock
25 mg	$1,780	In Stock	In Stock
50 mg	$2,380	In Stock	In Stock
100 mg	$3,230	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$987	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.35%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Pentiapine (CGS 10746) is a small-molecule inhibitor and a dopamine release inhibitor with cell permeability, used in neuropharmacological research to modulate dopaminergic signaling, holding significant application value in studies related to nervous system mechanisms.
In vivo	Methods: Mice were administered different doses of Pentiapine (0.5, 1, 2, 4, 8, 16, 24, 32 mg/kg) and morphine, and locomotor activity was measured through behavioral testing. Results: Pentiapine dose-dependently reduced locomotor activity in mice and decreased morphine-induced hyperactivity. Newman-Keuls post-hoc comparisons showed that the morphine plus saline group exhibited greater activity than the morphine plus 2 (P<0.05), 4, 8, 16, 24, and 32 (P<0.01) mg/kg Pentiapine groups; the morphine plus 0.5, 1, and 2 mg/kg Pentiapine groups also showed greater activity than the morphine plus 4, 8, 16, 24, and 32 mg/kg Pentiapine groups (P<0.01). [1] Methods: Using the conditioned place preference (CPP) model, mice were administered MDMA or cocaine and treated with 30 mg/kg Pentiapine. Results: 30 mg/kg Pentiapine completely blocked MDMA-induced CPP and prevented the establishment of cocaine CPP. [2]
Synonyms	CGS 10746

Chemical Properties

Molecular Weight	299.39
Formula	C₁₅H₁₇N₅S
Cas No.	81382-51-6
Smiles	CN1CCN(CC1)C1=Nc2ccccc2Sc2nccn12
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (334.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3401 mL	16.7006 mL	33.4012 mL	167.0062 mL
5 mM	0.6680 mL	3.3401 mL	6.6802 mL	33.4012 mL
10 mM	0.3340 mL	1.6701 mL	3.3401 mL	16.7006 mL
20 mM	0.1670 mL	0.8350 mL	1.6701 mL	8.3503 mL
50 mM	0.0668 mL	0.3340 mL	0.6680 mL	3.3401 mL
100 mM	0.0334 mL	0.1670 mL	0.3340 mL	1.6701 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.