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ELN318463 racemate

Name: ELN318463 racemate
Brand: TargetMol
SKU: T11178L
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11178LCas No. 851599-82-1

Alias ELN318463 (racemate), ELN 318463 racemate

ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

ELN318463 racemate

🥰Excellent

Purity: 99.69%

Catalog No. T11178LAlias ELN318463 (racemate), ELN 318463 racemateCas No. 851599-82-1

ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

Pack Size	Price	Availability
1 mg	$165	In Stock
5 mg	$412	In Stock
10 mg	$648	In Stock
25 mg	$954	In Stock
50 mg	$1,300	In Stock
100 mg	$1,750	In Stock
1 mL x 10 mM (in DMSO)	$471	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.69%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
In vitro	ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively[1].
In vivo	Brain levels of ELN318463 (30 mg/kg) are 0.754 μM in FVB brains and 0.69 μM, and of ELN318463(100 mg/kg) are 2.7 μM in FVB brains and 1.87 μM in PDAPP brains[1].
Synonyms	ELN318463 (racemate), ELN 318463 racemate

Chemical Properties

Molecular Weight	471.8
Formula	C₁₉H₂₀BrClN₂O₃S
Cas No.	851599-82-1
Smiles	N(S(=O)(=O)C1=CC=C(Cl)C=C1)(CC2=CC=C(Br)C=C2)C3C(=O)NCCCC3
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1195 mL	10.5977 mL	21.1954 mL	105.9771 mL
5 mM	0.4239 mL	2.1195 mL	4.2391 mL	21.1954 mL
10 mM	0.2120 mL	1.0598 mL	2.1195 mL	10.5977 mL
20 mM	0.1060 mL	0.5299 mL	1.0598 mL	5.2989 mL
50 mM	0.0424 mL	0.2120 mL	0.4239 mL	2.1195 mL
100 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0598 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc