Shopping Cart

Your shopping cart is currently empty

ELN318463 racemate

Name: ELN318463 racemate
Brand: TargetMol
SKU: T11178L
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T11178LCas No. 851599-82-1

Alias ELN318463 (racemate), ELN 318463 racemate

ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

ELN318463 racemate

Copy Product Info

🥰Excellent

Purity: 99.69%

Catalog No. T11178LAlias ELN318463 (racemate), ELN 318463 racemateCas No. 851599-82-1

ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$165	In Stock	In Stock
5 mg	$412	In Stock	In Stock
10 mg	$648	In Stock	In Stock
25 mg	$954	In Stock	In Stock
50 mg	$1,300	In Stock	In Stock
100 mg	$1,750	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$471	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
In vitro	ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively[1].
In vivo	Brain levels of ELN318463 (30 mg/kg) are 0.754 μM in FVB brains and 0.69 μM, and of ELN318463(100 mg/kg) are 2.7 μM in FVB brains and 1.87 μM in PDAPP brains[1].
Synonyms	ELN318463 (racemate), ELN 318463 racemate

Chemical Properties

Molecular Weight	471.8
Formula	C₁₉H₂₀BrClN₂O₃S
Cas No.	851599-82-1
Smiles	N(S(=O)(=O)C1=CC=C(Cl)C=C1)(CC2=CC=C(Br)C=C2)C3C(=O)NCCCC3
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1195 mL	10.5977 mL	21.1954 mL	105.9771 mL
5 mM	0.4239 mL	2.1195 mL	4.2391 mL	21.1954 mL
10 mM	0.2120 mL	1.0598 mL	2.1195 mL	10.5977 mL
20 mM	0.1060 mL	0.5299 mL	1.0598 mL	5.2989 mL
50 mM	0.0424 mL	0.2120 mL	0.4239 mL	2.1195 mL
100 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0598 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc