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Anti-GFR Alpha-1/GFRA1 Antibody (4D654)
🥰Excellent
Catalog No. TMAY-03157
Anti-GFR Alpha-1/GFRA1 Antibody (4D654) is a Rabbit antibody targeting GFR Alpha-1/GFRA1. Anti-GFR Alpha-1/GFRA1 Antibody (4D654) can be used in ELISA,IHC-P.
Anti-GFR Alpha-1/GFRA1 Antibody (4D654)
Anti-GFR Alpha-1/GFRA1 Antibody (4D654)
🥰Excellent
Catalog No. TMAY-03157
Anti-GFR Alpha-1/GFRA1 Antibody (4D654) is a Rabbit antibody targeting GFR Alpha-1/GFRA1. Anti-GFR Alpha-1/GFRA1 Antibody (4D654) can be used in ELISA,IHC-P.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-GFR Alpha-1/GFRA1 Antibody (4D654) is a Rabbit antibody targeting GFR Alpha-1/GFRA1. Anti-GFR Alpha-1/GFRA1 Antibody (4D654) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4D654 |
| Reactivity | Mouse |
| Verified Activity | 1. Immunochemical staining of mouse GFRa1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of mouse GFRa1 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GFRA1 (rM GFRA1; TMPY-01088; AAB86600.1; Met 1-Ser 425). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse GFRA1 protein (TMPY-01088) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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