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IQ-3

Name: IQ-3
Brand: TargetMol
SKU: T8477
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8477Cas No. 312538-03-7

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.

IQ-3

🥰Excellent

Catalog No. T8477Cas No. 312538-03-7

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$77	In Stock
10 mg	$117	In Stock
25 mg	$231	In Stock
50 mg	$369	In Stock
100 mg	$549	In Stock

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Batch Information

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Purity:≥98%

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Product Introduction

Bioactivity

Description	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
Targets&IC50	JNK3:66 nM(Kd), MKNK2:1.2 μM (Kd), JNK2:290 nM(Kd), JNK1:240 nM(Kd), CK1δ:0.56 μM (Kd), PI3Kγ:0.43 μM (Kd)

Chemical Properties

Molecular Weight	341.32
Formula	C₂₀H₁₁N₃O₃
Cas No.	312538-03-7
Smiles	O=C(ON=C1c2ccccc2-c2nc3ccccc3nc12)c1ccco1
Relative Density.	1.44 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.41 mg/mL (10 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9298 mL	14.6490 mL	29.2980 mL	146.4901 mL
5 mM	0.5860 mL	2.9298 mL	5.8596 mL	29.2980 mL
10 mM	0.2930 mL	1.4649 mL	2.9298 mL	14.6490 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc