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SHP2-D26

Name: SHP2-D26
Brand: TargetMol
SKU: T40121
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40121Cas No. 2458219-65-1

SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.

SHP2-D26

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Catalog No. T40121Cas No. 2458219-65-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$235	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.
Targets&IC50	SHP2:2.6 nM (DC50), SHP2:6.0 nM (DC50)
In vitro	In cellular assays utilizing KYSE520 and MV-4-11 cell lines, SHP2-D26 reduced SHP2 protein levels in a dose- and time-dependent manner with DC50 values of 6.0 nM and 2.6 nM respectively. Complete depletion was achieved by 8 hours at 100 nM. Functionally, the compound exhibited cytotoxicity against these cancer cell lines after a 4-day incubation with IC50 values of 0.66 μM and 0.99 nM [1].

Chemical Properties

Molecular Weight	1115.9
Formula	C₅₆H₇₉ClN₁₂O₆S₂
Cas No.	2458219-65-1
Smiles	C([C@@H](NC(CCCCCCCCN1CCN(C(CCC(NC2=C(Cl)C(SC=3C(N)=NC(=CN3)N4CCC(C)(N)CC4)=CC=C2)=O)=O)CC1)=O)[C@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (58.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8961 mL	4.4807 mL	8.9614 mL	44.8069 mL
5 mM	0.1792 mL	0.8961 mL	1.7923 mL	8.9614 mL
10 mM	0.0896 mL	0.4481 mL	0.8961 mL	4.4807 mL
20 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL
50 mM	0.0179 mL	0.0896 mL	0.1792 mL	0.8961 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc