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SHP2-D26

Name: SHP2-D26
Brand: TargetMol
SKU: T40121
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40121Cas No. 2458219-65-1

SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.

SHP2-D26

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Catalog No. T40121Cas No. 2458219-65-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$235	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.
Targets&IC50	SHP2:2.6 nM (DC50), SHP2:6.0 nM (DC50)
In vitro	In cellular assays utilizing KYSE520 and MV-4-11 cell lines, SHP2-D26 reduced SHP2 protein levels in a dose- and time-dependent manner with DC50 values of 6.0 nM and 2.6 nM respectively. Complete depletion was achieved by 8 hours at 100 nM. Functionally, the compound exhibited cytotoxicity against these cancer cell lines after a 4-day incubation with IC50 values of 0.66 μM and 0.99 nM [1].

Chemical Properties

Molecular Weight	1115.9
Formula	C₅₆H₇₉ClN₁₂O₆S₂
Cas No.	2458219-65-1
Smiles	C([C@@H](NC(CCCCCCCCN1CCN(C(CCC(NC2=C(Cl)C(SC=3C(N)=NC(=CN3)N4CCC(C)(N)CC4)=CC=C2)=O)=O)CC1)=O)[C@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (58.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8961 mL	4.4807 mL	8.9614 mL	44.8069 mL
5 mM	0.1792 mL	0.8961 mL	1.7923 mL	8.9614 mL
10 mM	0.0896 mL	0.4481 mL	0.8961 mL	4.4807 mL
20 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL
50 mM	0.0179 mL	0.0896 mL	0.1792 mL	0.8961 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc