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F15845

Catalog No. T61540 CAS 470454-73-0

F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1].

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F15845, CAS 470454-73-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 2,140.00
50 mg	6-8 weeks	$ 2,785.00
100 mg	6-8 weeks	$ 3,520.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1].
In vitro	F 15845, at concentrations ranging from 10 nM to 10 μM, has been shown to concentration-dependently mitigate veratrine-induced diastolic contracture in isolated atria, with an IC50 value of 0.14 μM [1]. Additionally, when administered at 0.1 to 10 μM, it effectively preserves the viability of isolated cardiomyocytes challenged with lysophosphatidylcholine (LPC) [1]. At a specific concentration of 0.3 μM, F 15845 significantly counteracts the increase in sodium levels ([Na+]) observed during no-flow ischemia, and when applied at the same concentration over a duration of 0-35 minutes, it not only delays the reduction in [Na+] but also prominently marks and sustains it upon reperfusion [1].
In vivo	F 15845, administered intravenously at doses of 5 mg/kg, demonstrates significant cardioprotective effects in anesthetized rats. This includes a substantial reduction in infarct size, a decrease in troponin I levels, and the prevention of long-term infarct size expansion, underscoring its potential therapeutic benefits in cardiac injury models.

Molecular Weight	375.55
Formula	C20H25NO2S2
CAS No.	470454-73-0

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

F15845 470454-73-0 inhibitor inhibit

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