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Tranexamic acid

Name: Tranexamic acid
Brand: TargetMol
SKU: T0949
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0949Cas No. 1197-18-8

Alias Tranexamsaeure, Amstat

Tranexamic acid (Amstat) is an Antifibrinolytic Agent. The physiologic effect of tranexamic acid is by means of Decreased Fibrinolysis.

Tranexamic acid

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Purity: 99.79%

Catalog No. T0949Alias Tranexamsaeure, AmstatCas No. 1197-18-8

Tranexamic acid (Amstat) is an Antifibrinolytic Agent. The physiologic effect of tranexamic acid is by means of Decreased Fibrinolysis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$30	-	In Stock
5 g	$48	-	In Stock
10 g	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

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Product Introduction

Tranexamic acid AI Summary

Tranexamic acid exhibits various bioactivities across multiple biological systems and assays. In terms of pharmacokinetics, it undergoes ester hydrolysis in human blood with a half-life of 4.0 hours and in human plasma with a half-life of 0.02 hours. The compound has shown an oral bioavailability of 55.0% in humans and demonstrates binding to liposomes with different affinities. It exhibits a volume of distribution at steady state of 0.38 L/kg, a half-life of 2.3 hours, and a clearance rate of 2.4 mL/min/kg after intravenous administration. Pharmacologically, Tranexamic acid inhibits plasmin activity and affects plasminogen interactions with fibrinogen, showing various IC50 values in different assays. It has demonstrated antifibrinolytic activity in rat and mouse bleeding models, reducing bleeding time post-challenge with tissue plasminogen activator (tPA). It also inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected CHO cells. In terms of safety, Tranexamic acid shows low hepatotoxicity with a DILI severity class index of 0.0 and exhibits minimal inhibition of cell viability in various cell types, including human liver cells. It demonstrates antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in several cell lines and shows binding affinity to the plasminogen K1 domain. Additionally, it modulates other bioactivities such as permeability across human Caco2 cells, inhibition of human HDAC6, and involvement in various enzyme assays, indicating its broad spectrum of biological interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tranexamic acid (Amstat) is an Antifibrinolytic Agent. The physiologic effect of tranexamic acid is by means of Decreased Fibrinolysis.
Targets&IC50	Antifibrinolytic:5 mM
Synonyms	Tranexamsaeure, Amstat

Chemical Properties

Molecular Weight	157.21
Formula	C₈H₁₅NO₂
Cas No.	1197-18-8
Smiles	NC[C@H]1CC[C@@H](CC1)C(O)=O
Relative Density.	1.096g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 83.33 mg/mL (530.06 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.3609 mL	31.8046 mL	63.6092 mL	318.0459 mL
5 mM	1.2722 mL	6.3609 mL	12.7218 mL	63.6092 mL
10 mM	0.6361 mL	3.1805 mL	6.3609 mL	31.8046 mL
20 mM	0.3180 mL	1.5902 mL	3.1805 mL	15.9023 mL
50 mM	0.1272 mL	0.6361 mL	1.2722 mL	6.3609 mL
100 mM	0.0636 mL	0.3180 mL	0.6361 mL	3.1805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc