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1-Acetyl-β-carboline

Name: 1-Acetyl-β-carboline
Brand: TargetMol
SKU: TN2524
Price: 396 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2524Cas No. 50892-83-6

Alias 1-Acetyl-beta-carboline

1-Acetyl-β-carboline is a bioactive metabolite derived from Streptomyces kasugaensis that exhibits antibacterial properties, enhances tyrosinase activity, reduces ERK phosphorylation, and increases melanin production, while demonstrating antibacterial efficacy against methicillin-resistant Staphylococcus aureus strains with minimum inhibitory concentrations ranging from 128 to 256 μg/mL, supporting the use of 1-Acetyl-β-carboline in the investigation in antimicrobial and pigmentation-related biochemical research.

1-Acetyl-β-carboline

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Purity: 99.62%

Catalog No. TN2524Alias 1-Acetyl-beta-carbolineCas No. 50892-83-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$396	-	In Stock
5 mg	$1,030	-	In Stock
10 mg	$1,390	-	In Stock
25 mg	$1,980	-	In Stock
50 mg	$2,790	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	1-Acetyl-β-carboline is a bioactive metabolite derived from Streptomyces kasugaensis that exhibits antibacterial properties, enhances tyrosinase activity, reduces ERK phosphorylation, and increases melanin production, while demonstrating antibacterial efficacy against methicillin-resistant Staphylococcus aureus strains with minimum inhibitory concentrations ranging from 128 to 256 μg/mL, supporting the use of 1-Acetyl-β-carboline in the investigation in antimicrobial and pigmentation-related biochemical research.
In vitro	1-Acetyl-β-carboline exhibits antibacterial activity against MRSA strains, with a Minimum Inhibitory Concentration (MIC) ranging from 128 to 256 ug/mL. In combination with β-lactam antibiotics, 1-Acetyl-β-carboline shows synergistic effects at concentrations of 32-64 ug/mL, enhancing the activity of these antibiotics against resistant strains. Furthermore, in B16F10 melanoma cells, 1-Acetyl-β-carboline (12.5-50 μM) acts as a melanogenic agent, increasing intracellular melanin content and tyrosinase activity over 72 hours [2][3].
Synonyms	1-Acetyl-beta-carboline

Chemical Properties

Molecular Weight	210.23
Formula	C₁₃H₁₀N₂O
Cas No.	50892-83-6
Smiles	O=C(C1=NC=CC=2C=3C=CC=CC3NC12)C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (190.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7567 mL	23.7835 mL	47.5670 mL	237.8348 mL
5 mM	0.9513 mL	4.7567 mL	9.5134 mL	47.5670 mL
10 mM	0.4757 mL	2.3783 mL	4.7567 mL	23.7835 mL
20 mM	0.2378 mL	1.1892 mL	2.3783 mL	11.8917 mL
50 mM	0.0951 mL	0.4757 mL	0.9513 mL	4.7567 mL
100 mM	0.0476 mL	0.2378 mL	0.4757 mL	2.3783 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc