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GSK299115A

Name: GSK299115A
Brand: TargetMol
SKU: T27471
Price: 336 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27471Cas No. 864082-35-9

Alias GSK-299115A, GSK 299115A

GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.

GSK299115A

🥰Excellent

Purity: 99.81%

Catalog No. T27471Alias GSK-299115A, GSK 299115ACas No. 864082-35-9

GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.

Pack Size	Price	Availability
1 mg	$336	In Stock
5 mg	$813	In Stock
10 mg	$1,130	In Stock
25 mg	$1,680	In Stock
50 mg	$2,260	In Stock
100 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$995	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.81%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.
Synonyms	GSK-299115A, GSK 299115A

Chemical Properties

Molecular Weight	415.27
Formula	C₂₀H₁₆Cl₂N₄O₂
Cas No.	864082-35-9
Smiles	C(NC=1C=C2C(=CC1)NN=C2)(=O)C=3C(CC(=O)NC3C)C4=CC(Cl)=C(Cl)C=C4
Relative Density.	1.479 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (120.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4081 mL	12.0404 mL	24.0807 mL	120.4036 mL
5 mM	0.4816 mL	2.4081 mL	4.8161 mL	24.0807 mL
10 mM	0.2408 mL	1.2040 mL	2.4081 mL	12.0404 mL
20 mM	0.1204 mL	0.6020 mL	1.2040 mL	6.0202 mL
50 mM	0.0482 mL	0.2408 mL	0.4816 mL	2.4081 mL
100 mM	0.0241 mL	0.1204 mL	0.2408 mL	1.2040 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc