TMX-4153

Name: TMX-4153
Brand: TargetMol
SKU: T80974
Rating: 4.5 (1 reviews)

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Catalog No. T80974Cas No. 2867519-91-1

TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase complex, demonstrating a K D of 42 nM. It is applicable in the synthesis of PROTAC [1].

TMX-4153

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Catalog No. T80974Cas No. 2867519-91-1

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase complex, demonstrating a K D of 42 nM. It is applicable in the synthesis of PROTAC [1].
In vitro	TMX-4153, at concentrations of 0.01, 0.05, 0.1, 0.5, and 1 µM and with an exposure duration of 6 hours, selectively degrades PIP4K2C in MOLT-4 cells [1].

Chemical Properties

Molecular Weight	1079.75
Formula	C₅₉H₆₇ClN₁₀O₆S
Cas No.	2867519-91-1
Smiles	O=C1C2(CCN1C=3C=C(NC=4N=C(C(Cl)=CN4)C5=CC(=CC=C5)C6=CC=CC=C6)C=NC3)CCN(C(CCCCCC(N[C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)=O)CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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