6-Bromohexylphosphonic acid

Name: 6-Bromohexylphosphonic acid
Brand: TargetMol
SKU: T14056
Rating: 4.5 (1 reviews)

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Catalog No. T14056Cas No. 133345-66-1

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

6-Bromohexylphosphonic acid

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Catalog No. T14056Cas No. 133345-66-1

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].
In vitro	PROTACs consist of two ligands linked together: one binding to an E3 ubiquitin ligase and the other to a target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	245.05
Formula	C₆H₁₄BrO₃P
Cas No.	133345-66-1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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