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Zotizalkib
🥰Excellent
Catalog No. T9414Cas No. 2648641-36-3
Alias TPX-0131, TPX0131
Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.
Zotizalkib
🥰Excellent
Purity: 98.7%
Catalog No. T9414Alias TPX-0131, TPX0131Cas No. 2648641-36-3
Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $129 | In Stock | |
| 5 mg | $319 | In Stock | |
| 10 mg | $513 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,550 | In Stock | |
| 100 mg | $2,180 | In Stock | |
| 200 mg | $2,950 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $352 | In Stock |
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Purity:98.7%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer. |
| Targets&IC50 | ALK (WT):1.4 nM |
| In vitro | Zotizalkib effectively inhibited wild-type ALK with an IC50 value of 1.4 nM, and also showed inhibitory activity against 26 ALK resistance mutations. Zotizalkib also showed effective inhibition of ALK autophosphorylation in Ba/F3 cells expressing EML4-ALK G1202R, EML4-ALK G1202R/L1196M or EML4-ALK G1202R/L1198F mutations, with an IC50 value of about 3-10 nM. [1] |
| In vivo | Zotizalkib was administered orally at a dose of 2-10 mg/kg twice daily for 2 weeks, with the 2 mg/kg, 5 mg/kg, and 10 mg/kg doses exhibiting 64%, 120%, and 200% dose-dependent tumor growth inhibition, respectively. [1] |
| Synonyms | TPX-0131, TPX0131 |
| Molecular Weight | 447.41 |
| Formula | C21H20F3N5O3 |
| Cas No. | 2648641-36-3 |
| Smiles | C(F)(F)[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC(C)(C)COC=5C(C2)=CC(F)=CC5)OC1 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (44.7 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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