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Fengabine

Name: Fengabine
Brand: TargetMol
SKU: T27310
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27310Cas No. 80018-06-0

Alias SL-79229, SL79229, SL 79-229, SL 79229, SL 79.229-00, SL 79,229-00

Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.

Fengabine

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Purity: 99.37%

Catalog No. T27310Alias SL-79229, SL79229, SL 79-229, SL 79229, SL 79.229-00, SL 79,229-00Cas No. 80018-06-0

Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$74	-	In Stock
10 mg	$109	-	In Stock
25 mg	$212	-	In Stock
50 mg	$289	-	In Stock
100 mg	$428	-	In Stock
200 mg	$612	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.37%

Appearance:Oil

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.
In vivo	Fengabine (50-1000 mg/kg; i.p.) does not alter norepinephrine uptake but accelerates the turnover rate of norepinephrine in the rat brain as demonstrated by the enhancement of the alpha-methyl-p-tyrosine-induced disappearance of norepinephrine in the hypothalamus.[4]Fengabine (100 or 200 mg/kg; i.p., b.i.d.), given for 14 days, causes a desensitization of isoprenaline-stimulated adenylate cyclase in septal and cortical slices of the rat but fails to modify cortical beta, alpha-1 or alpha-2 adrenoceptor binding sites.[4]
Synonyms	SL-79229, SL79229, SL 79-229, SL 79229, SL 79.229-00, SL 79,229-00

Chemical Properties

Molecular Weight	322.23
Formula	C₁₇H₁₇Cl₂NO
Cas No.	80018-06-0
Smiles	C(=NCCCC)(C1=C(O)C=CC(Cl)=C1)C2=C(Cl)C=CC=C2
Relative Density.	1.24g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (139.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1034 mL	15.5169 mL	31.0337 mL	155.1687 mL
5 mM	0.6207 mL	3.1034 mL	6.2067 mL	31.0337 mL
10 mM	0.3103 mL	1.5517 mL	3.1034 mL	15.5169 mL
20 mM	0.1552 mL	0.7758 mL	1.5517 mL	7.7584 mL
50 mM	0.0621 mL	0.3103 mL	0.6207 mL	3.1034 mL
100 mM	0.0310 mL	0.1552 mL	0.3103 mL	1.5517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc