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NS3694

Name: NS3694
Brand: TargetMol
SKU: T22119
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22119Cas No. 426834-38-0

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.

NS3694

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Purity: 99.83%

Catalog No. T22119Cas No. 426834-38-0

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$538	In Stock	In Stock
500 mg	$1,150	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.

In vitro

NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis[1].

Chemical Properties

Molecular Weight	358.7
Formula	C₁₅H₁₀ClF₃N₂O₃
Cas No.	426834-38-0
Smiles	OC(=O)c1ccc(Cl)cc1NC(=O)Nc1cccc(c1)C(F)(F)F
Relative Density.	1.574g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (696.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7878 mL	13.9392 mL	27.8784 mL	139.3922 mL
5 mM	0.5576 mL	2.7878 mL	5.5757 mL	27.8784 mL
10 mM	0.2788 mL	1.3939 mL	2.7878 mL	13.9392 mL
20 mM	0.1394 mL	0.6970 mL	1.3939 mL	6.9696 mL
50 mM	0.0558 mL	0.2788 mL	0.5576 mL	2.7878 mL
100 mM	0.0279 mL	0.1394 mL	0.2788 mL	1.3939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc