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TTP-8307

Name: TTP-8307
Brand: TargetMol
SKU: T13221
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13221Cas No. 950225-08-8

Alias TTP8307

TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections.

TTP-8307

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Purity: 98.95%

Catalog No. T13221Alias TTP8307Cas No. 950225-08-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$423	In Stock	In Stock
25 mg	$822	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
100 mg	$1,990	-	In Stock
200 mg	$2,680	-	In Stock
1 mL x 10 mM (in DMSO)	$318	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.95%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections.
Targets&IC50	Sabin poliovirus:0.85 μM (EC50), CVB3 Nancy:1.2 μM (EC50), Enteroviruses A16 and A21:5.34 μM (EC50)
In vitro	TTP-8307 targeted non-structural protein 3A and inhibited the replication of enterovirus B3 (CVB3 Nancy) with an EC50 of 1.2 μM. In addition, TTP-8307 inhibited the replication of three Sabin poliovirus strains, as well as enteroviruses A16 and A21, with EC50s of 0.85 and 5.34 μM, respectively.Meanwhile, TTP-8307 inhibited the replication of human rhinoviruses (HRVs) 2, 29, 39, 45, 63 and 85 was also inhibitory. Mutations in non-structural protein 3A caused resistance to TTP-8307, a novel enterovirus replication inhibitor. In addition, TTP-8307 inhibits OSBP-dependent viruses, including encephalomyelitis virus (EMCV) and hepatitis C virus (HCV). [1][2]
Synonyms	TTP8307

Chemical Properties

Molecular Weight	436.48
Formula	C₂₇H₂₁FN₄O
Cas No.	950225-08-8
Smiles	C(N[C@H](C)C1=CC=C(F)C=C1)(=O)C=2C=C(C=3NC(=NC3)C4=CC5=C(C=N4)C=CC=C5)C=CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (183.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2911 mL	11.4553 mL	22.9106 mL	114.5528 mL
5 mM	0.4582 mL	2.2911 mL	4.5821 mL	22.9106 mL
10 mM	0.2291 mL	1.1455 mL	2.2911 mL	11.4553 mL
20 mM	0.1146 mL	0.5728 mL	1.1455 mL	5.7276 mL
50 mM	0.0458 mL	0.2291 mL	0.4582 mL	2.2911 mL
100 mM	0.0229 mL	0.1146 mL	0.2291 mL	1.1455 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc