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Anti-RAGE Antibody (4J597)
😃Good
Catalog No. TMAY-01944
Alias RAGE, AGER, advanced glycosylation end product-specific receptor
Anti-RAGE Antibody (4J597) is a Mouse antibody targeting RAGE. Anti-RAGE Antibody (4J597) can be used in IHC-P.
Anti-RAGE Antibody (4J597)
Anti-RAGE Antibody (4J597)
😃Good
Catalog No. TMAY-01944Alias RAGE, AGER, advanced glycosylation end product-specific receptor
Anti-RAGE Antibody (4J597) is a Mouse antibody targeting RAGE. Anti-RAGE Antibody (4J597) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | RAGE, AGER, advanced glycosylation end product-specific receptor |
| Ig Type | Mouse IgG1 |
| Clone | 4J597 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human AGER in human kidney with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human AGER in human lung with mouse monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RAGE/AGER (rh RAGE/AGER; TMPY-02927; NP_001127; Met1-Ala344). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS with 0.02% Tween 80, pH7.0 |
| Research Background | Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human RAGE/AGER Protein (TMPY-02927) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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