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Anti-ALOX12 Polyclonal Antibody

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Catalog No. TMAB-00097
Alias Polyunsaturated fatty acid lipoxygenase ALOX12, Platelet-type lipoxygenase 12, LOG12, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, Arachidonate (15S)-lipoxygenase, Arachidonate (12S)-lipoxygenase (12S-LOX;12S-lipoxygenase), ALOX12, 12LO

Anti-ALOX12 Polyclonal Antibody is a Rabbit antibody targeting ALOX12. Anti-ALOX12 Polyclonal Antibody can be used in WB.

Anti-ALOX12 Polyclonal Antibody

Anti-ALOX12 Polyclonal Antibody

😃Good
Catalog No. TMAB-00097Alias Polyunsaturated fatty acid lipoxygenase ALOX12, Platelet-type lipoxygenase 12, LOG12, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, Arachidonate (15S)-lipoxygenase, Arachidonate (12S)-lipoxygenase (12S-LOX;12S-lipoxygenase), ALOX12, 12LO
Anti-ALOX12 Polyclonal Antibody is a Rabbit antibody targeting ALOX12. Anti-ALOX12 Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3727-10 days
200 μL$5297-10 days
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Product Introduction

Bioactivity
Description
Anti-ALOX12 Polyclonal Antibody is a Rabbit antibody targeting ALOX12. Anti-ALOX12 Polyclonal Antibody can be used in WB.
SynonymsPolyunsaturated fatty acid lipoxygenase ALOX12, Platelet-type lipoxygenase 12, LOG12, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, Arachidonate (15S)-lipoxygenase, Arachidonate (12S)-lipoxygenase (12S-LOX;12S-lipoxygenase), ALOX12, 12LO
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Rat)
Verified Activity
Sample:
Lane 1: Esophagus (Mouse) Lysate at 40 μg
Lane 2: A431 (Human) Cell Lysate at 30 μg
Lane 3: Hela (Human) Cell Lysate at 30 μg
Lane 4: A549 (Human) Cell Lysate at 30 μg
Lane 5: 293T (Human) Cell Lysate at 30 μg
Lane 6: U937 (Human) Cell Lysate at 30 μg
Lane 7: K562 (Human) Cell Lysate at 30 μg
Primary: Anti-ALOX12 (TMAB-00097) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 76 kDa
Observed band size: 76 kDa
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
Tissue SpecificityExpressed in vascular smooth muscle cells.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThis gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human 12 Lipoxygenase
Antigen Species
Human
Gene Name
ALOX12B
Gene ID
Protein Name
Arachidonate 12-lipoxygenase, 12R-type
Uniprot ID
Biology Area
Lipid metabolism,Lipases,Cell differentiation,Lipases
Function
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750,
Chemical Properties
Molecular WeightTheoretical: 76 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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