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SMU-V18

Name: SMU-V18
Brand: TargetMol
SKU: T213065
Rating: 4.5 (1 reviews)

Catalog No. T213065 Copy Product Info

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SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor with an EC50 of 6.2 μM. It suppresses VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with the early stages of viral infection and is effective against wild-type VSV (VSV-WT). Additionally, it suppresses VSV-GFP in mouse tissues and extends survival in mice. SMU-V18 is useful for studying vesicular stomatitis virus (VSV) infections.

SMU-V18

Copy Product Info

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Catalog No. T213065

SMU-V18

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor with an EC50 of 6.2 μM. It suppresses VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with the early stages of viral infection and is effective against wild-type VSV (VSV-WT). Additionally, it suppresses VSV-GFP in mouse tissues and extends survival in mice. SMU-V18 is useful for studying vesicular stomatitis virus (VSV) infections.
In vitro	SMU-V18 significantly inhibits VSV-GFP replication in HeLa cells at concentrations of 1.2-40 μM over 24 hours, with an EC50 of 6.2 μM, reducing GFP fluorescence intensity, VSV-P mRNA, and GFP expression. It also effectively suppresses the release of progeny VSV-GFP at 5-20 μM during 24-hour incubation. In Vero cells, SMU-V18 at 5-20 μM over 6-24 hours markedly inhibits VSV-WT replication, decreases VSV-WT plaque formation, and lowers viral mRNA levels across different MOI and incubation durations. Real Time qPCR analysis shows reduced VSV-P mRNA levels after treatment.
In vivo	SMU-V18 (25-50 mg/kg, intraperitoneal injection, once daily for 5 days) significantly reduces VSV-GFP replication in mouse tissues.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc