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Xanthine amine congener dihydrochloride

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Catalog No. T39387Cas No. 1962928-23-9
Alias Xanthine amine congener dihydrochloride, XAC dihydrochloride

Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors with IC50 values of 1.8 nM for A1 and 114 nM for A2, also functions as a convulsant agent in mouse models.

Xanthine amine congener dihydrochloride
Other Forms of Xanthine amine congener dihydrochloride:

Xanthine amine congener dihydrochloride

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Catalog No. T39387Alias Xanthine amine congener dihydrochloride, XAC dihydrochlorideCas No. 1962928-23-9
Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors with IC50 values of 1.8 nM for A1 and 114 nM for A2, also functions as a convulsant agent in mouse models.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$67835 days35 days
50 mg$2,78035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors with IC50 values of 1.8 nM for A1 and 114 nM for A2, also functions as a convulsant agent in mouse models.
Targets&IC50
A1 receptor:1.8 nM (IC50), A2 receptor:114 nM (IC50)
In vivo
Xanthine amine congener dihydrochloride (XAC) demonstrates greater potency as a convulsant agent compared to caffeine or theophylline when administered through infusion at a dosage of 39.8 mg/kg. However, XAC exhibits no convulsant effects when delivered via intraperitoneal (i.p.) injection, with the seizure threshold exceeding 1000 mg/kg. This observation is supported by studies conducted on mice, utilizing a single infusion injection of 39.8 mg/kg, thereby positioning XAC as a more potent convulsant than either caffeine or theophylline under specified conditions. [1]
SynonymsXanthine amine congener dihydrochloride, XAC dihydrochloride
Chemical Properties
Molecular Weight501.41
FormulaC21H30Cl2N6O4
Cas No.1962928-23-9
SmilesCl.Cl.CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)NCCN)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Xanthine amine congener DihydrochlorideXanthine amine congenerXAC DihydrochlorideXAC
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