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Anti-IL-1RAP/IL-1RAcP Antibody (7Z148)

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Catalog No. TMAY-00301
Alias interleukin 1 receptor accessory protein

Anti-IL-1RAP/IL-1RAcP Antibody (7Z148) is a Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (7Z148) can be used in ELISA.

Anti-IL-1RAP/IL-1RAcP Antibody (7Z148)

Anti-IL-1RAP/IL-1RAcP Antibody (7Z148)

😃Good
Catalog No. TMAY-00301Alias interleukin 1 receptor accessory protein
Anti-IL-1RAP/IL-1RAcP Antibody (7Z148) is a Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (7Z148) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
20 μL$94 7-10 days
100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-IL-1RAP/IL-1RAcP Antibody (7Z148) is a Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (7Z148) can be used in ELISA.
Aliasinterleukin 1 receptor accessory protein
Ig Type
Monoclonal Mouse IgG1
Clone
7Z148
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1RAcP / IL-1R3 (rh IL-1RAcP / IL-1R3; TMPY-01251; NP_002173.1; Met1-Glu359). The IgG fraction of the cell culture supernatant was purified by Protein A affinity.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0
Research BackgroundInterleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human IL-1RAcP / IL-1R3 protein (TMPY-01251)
Antigen Species
Human
Biology Area
Neuroinflammation
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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