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RTICBM-189

Name: RTICBM-189
Brand: TargetMol
SKU: T9466
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9466Cas No. 551909-15-0

RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in the Ca2+ mobilization assay, and exhibits pIC50s of 5.29 for hCB1 and 6.25 for mCB1.

RTICBM-189

🥰Excellent

Purity: 99.96%

Catalog No. T9466Cas No. 551909-15-0

Pack Size	Price	Availability
2 mg	$31	In Stock
5 mg	$46	In Stock
10 mg	$80	In Stock
25 mg	$173	In Stock
50 mg	$278	In Stock
100 mg	$409	In Stock
200 mg	$579	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock

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Batch Information

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Purity:99.96%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in the Ca2+ mobilization assay, and exhibits pIC50s of 5.29 for hCB1 and 6.25 for mCB1.
Targets&IC50	CB1 (human):5.29 (pIC50), CB1:7.54 (pIC50), CB1 (mouse):6.25 (pIC50)

Chemical Properties

Molecular Weight	309.19
Formula	C₁₅H₁₄Cl₂N₂O
Cas No.	551909-15-0
Smiles	Clc1ccc(NC(=O)NCCc2cccc(Cl)c2)cc1
Relative Density.	1.330 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (323.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2343 mL	16.1713 mL	32.3426 mL	161.7129 mL
5 mM	0.6469 mL	3.2343 mL	6.4685 mL	32.3426 mL
10 mM	0.3234 mL	1.6171 mL	3.2343 mL	16.1713 mL
20 mM	0.1617 mL	0.8086 mL	1.6171 mL	8.0856 mL
50 mM	0.0647 mL	0.3234 mL	0.6469 mL	3.2343 mL
100 mM	0.0323 mL	0.1617 mL	0.3234 mL	1.6171 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc