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Ibrexafungerp

Name: Ibrexafungerp
Brand: TargetMol
SKU: T28051
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28051Cas No. 1207753-03-4

Alias SCY-078, SCY078, MK3118, MK 3118, GSK5458448, GSK 5458448

Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthase inhibitor with antifungal activity, disrupting fungal cell wall integrity, used in fungal infection research.

Ibrexafungerp

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Purity: 99.96%

Catalog No. T28051Alias SCY-078, SCY078, MK3118, MK 3118, GSK5458448, GSK 5458448Cas No. 1207753-03-4

Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthase inhibitor with antifungal activity, disrupting fungal cell wall integrity, used in fungal infection research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$179	In Stock	In Stock
5 mg	$469	-	In Stock
10 mg	$746	-	In Stock
25 mg	$1,150	-	In Stock
50 mg	$1,560	-	In Stock
100 mg	$2,080	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthase inhibitor with antifungal activity, disrupting fungal cell wall integrity, used in fungal infection research.
In vitro	Ibrexafungerp exhibited broad in vitro activity against a wide range of Candida spp. including Candida auriculata and Candida auriculata isolates with fks mutations, with minimum inhibitory concentrations (MIC50 and MIC90) of 0.5 μg/mL and 1.0 μg/mL, respectively, in more than 400 C. auris isolates.
In vivo	Methods: Ibrexafungerp (3.125, 12.5, 50 and 200 mg/kg, oral) was administered to mice for single-dose pharmacokinetic (PK) evaluation: plasma was collected from 3 mice groups at each time point, and plasma drug concentrations were determined by liquid chromatography-tandem mass spectrometry; a non-compartmental model was used in the pharmacokinetic analysis, and the elimination half-life was calculated by nonlinear least squares technique; the area under the concentration-time curve (AUC) was calculated by the trapezoidal rule. Results: The pharmacokinetics of Ibrexafungerp were relatively linear over the entire dose range, with an elimination half-life in plasma ranging from 5.9 h to 8.5 h; within the dose range, the maximum concentration (Cmax) of the drug in serum increased from 0.04 mg/L to 2.66 mg/L.[6]
Synonyms	SCY-078, SCY078, MK3118, MK 3118, GSK5458448, GSK 5458448

Chemical Properties

Molecular Weight	730.03
Formula	C₄₄H₆₇N₅O₄
Cas No.	1207753-03-4
Smiles	C[C@@]12[C@]3([C@@](C=4[C@@]([C@]5(C)[C@@](C)(CC4)[C@H](C(O)=O)[C@]([C@@H](C(C)C)C)(C)CC5)(CC3)[H])(C[C@H]([C@@H]1OC[C@]([C@@](C)(C)C)(C)N)N6C(=NC=N6)C=7C=CN=CC7)COC2)[H]
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (273.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3698 mL	6.8490 mL	13.6981 mL	68.4903 mL
5 mM	0.2740 mL	1.3698 mL	2.7396 mL	13.6981 mL
10 mM	0.1370 mL	0.6849 mL	1.3698 mL	6.8490 mL
20 mM	0.0685 mL	0.3425 mL	0.6849 mL	3.4245 mL
50 mM	0.0274 mL	0.1370 mL	0.2740 mL	1.3698 mL
100 mM	0.0137 mL	0.0685 mL	0.1370 mL	0.6849 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc