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MAGL-IN-4

Name: MAGL-IN-4
Brand: TargetMol
SKU: T9687
Price: 143 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9687Cas No. 2135785-20-3

Alias His121 ARG57

MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.

MAGL-IN-4

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Purity: 99.79%

Catalog No. T9687Alias His121 ARG57Cas No. 2135785-20-3

MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.

Pack Size	Price	Availability
1 mg	$143	In Stock
5 mg	$363	In Stock
10 mg	$538	In Stock
25 mg	$893	In Stock
50 mg	$1,180	In Stock
100 mg	$1,590	In Stock
1 mL x 10 mM (in DMSO)	$392	In Stock

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Batch Information

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Purity:99.79%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
Targets&IC50	MAGL:6.2 nM
In vitro	MAGL-IN-4 showed potent in vitro MAGL inhibitory activity (IC50 6.2 nM), good oral absorption and blood-brain barrier penetration[1].
In vivo	MAGL-IN-4 showed significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3-10 mg/kg, po. in mice[1].
Synonyms	His121 ARG57

Chemical Properties

Molecular Weight	364.82
Formula	C₁₈H₂₁ClN₂O₄
Cas No.	2135785-20-3
Smiles	Cc1ccc(COC2CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)cc1Cl
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 88 mg/mL (241.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7411 mL	13.7054 mL	27.4108 mL	137.0539 mL
5 mM	0.5482 mL	2.7411 mL	5.4822 mL	27.4108 mL
10 mM	0.2741 mL	1.3705 mL	2.7411 mL	13.7054 mL
20 mM	0.1371 mL	0.6853 mL	1.3705 mL	6.8527 mL
50 mM	0.0548 mL	0.2741 mL	0.5482 mL	2.7411 mL
100 mM	0.0274 mL	0.1371 mL	0.2741 mL	1.3705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc