Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PR-104 is a highly specific hypoxia-activated agent that cross-links DNA, enabling its application in various tumor xenograft models. Functioning as a pre-prodrug of nitrogen mustard, PR-104 undergoes efficient conversion to the dinitrobenzamide mustards alcohol form, known as PR-104A[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,310.00 | |
50 mg | 6-8 weeks | $ 1,710.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | PR-104 is a highly specific hypoxia-activated agent that cross-links DNA, enabling its application in various tumor xenograft models. Functioning as a pre-prodrug of nitrogen mustard, PR-104 undergoes efficient conversion to the dinitrobenzamide mustards alcohol form, known as PR-104A[1]. |
In vitro | PR-104 demonstrates differential effects under various conditions in SiHa cells, showing enhanced inhibition of radiation-induced DNA single-strand breaks in hypoxic conditions compared to aerobic conditions at a concentration of 80 μM for 1 hour. At a higher concentration of 100 μM for the same duration, it triggers the phosphorylation of Ser139 on histone H2AX. Furthermore, with a dosage of 0.266 mmol/kg over 18 hours, PR-104 exhibits efficacy against hypoxic cells post-irradiation. Its effectiveness varies across cell lines, exhibiting a range in IC50 values from as low as 0.51 μmol/L in H460 cells to as high as 7.3 μmol/L in PC3 prostate cells. |
In vivo | PR-104 (0.56 mmol/kg; i.v. or i.p.; 0~2 hours) makes the plasma area under the curve. PR-104 (0.23 mmol/kg; i.p.; 100 days) shows antitumor activity[1]. |
Molecular Weight | 579.27 |
Formula | C14H20BrN4O12PS |
CAS No. | 851627-62-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PR-104 851627-62-8 PR104 PR 104 inhibitor inhibit