β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.

β-glucuronidase (E. coli):164 nM(Ki), β-glucuronidase (E. coli):283 nM , β-glucuronidase (E. coli):283 nM

β-Glucuronidase-IN-1 (0.01-100 μM) inhibits E. coli β-glucuronidase activity in a dose-dependent manner(IC50 and Ki of 283 nM and 164 nM, respectively).[1]
β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells with EC50 of 17.7 nM.[1]

β-Glucuronidase-IN-1 (10 μg; oral gavage; twice per day; 11 days) shields the gastrointestinal epithelium of mice from damage induced by CPT-11, preserving the glandular structure in the treated intestinal tissues.[1]