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TDZD-8

🥰Excellent
Catalog No. T6187Cas No. 327036-89-5
Alias NP 01139, GSK-3β Inhibitor I

TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.

TDZD-8

TDZD-8

🥰Excellent
Purity: 99.61%
Catalog No. T6187Alias NP 01139, GSK-3β Inhibitor ICas No. 327036-89-5
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$42In StockIn Stock
10 mg$53In StockIn Stock
25 mg$77In StockIn Stock
50 mg$126In StockIn Stock
100 mg$198In StockIn Stock
1 mL x 10 mM (in DMSO)$46In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.61%
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Product Introduction

Bioactivity
Description
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
Targets&IC50
GSK-3β:2 μM
In vitro
TDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. [1] TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens. [2]
SynonymsNP 01139, GSK-3β Inhibitor I
Chemical Properties
Molecular Weight222.26
FormulaC10H10N2O2S
Cas No.327036-89-5
SmilesCn1sc(=O)n(Cc2ccccc2)c1=O
Relative Density.1.375 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 70 mg/mL (314.95 mM), Sonication is recommended.
Ethanol: 44.5 mg/mL (200.22 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.4992 mL22.4962 mL44.9924 mL224.9618 mL
5 mM0.8998 mL4.4992 mL8.9985 mL44.9924 mL
10 mM0.4499 mL2.2496 mL4.4992 mL22.4962 mL
20 mM0.2250 mL1.1248 mL2.2496 mL11.2481 mL
50 mM0.0900 mL0.4499 mL0.8998 mL4.4992 mL
100 mM0.0450 mL0.2250 mL0.4499 mL2.2496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TDZD-8TDZD8TDZD 8NP-01139NP01139InhibitorinhibitGSK-3βGSK-3beta Inhibitor IGSK-3b Inhibitor IGSK-3GSK3Glycogen synthase kinase-3Glycogen synthase kinase 3
Related Tags: buy TDZD-8 | purchase TDZD-8 | TDZD-8 cost | order TDZD-8 | TDZD-8 chemical structure | TDZD-8 in vitro | TDZD-8 formula | TDZD-8 molecular weight
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