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Medicarpin

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Catalog No. TN1918Cas No. 32383-76-9
Alias (-)-Medicarpin

N-Methylnicotinamide is one of the endogenous metabolites that ameliorates endothelial dysfunction.

Medicarpin

Medicarpin

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Purity: 99.86%
Catalog No. TN1918Alias (-)-MedicarpinCas No. 32383-76-9
N-Methylnicotinamide is one of the endogenous metabolites that ameliorates endothelial dysfunction.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117In StockIn Stock
5 mg$289In StockIn Stock
10 mg$428In StockIn Stock
25 mg$698In StockIn Stock
50 mg$968-In Stock
100 mg$1,280-In Stock
200 mg$1,760-In Stock
1 mL x 10 mM (in DMSO)$262In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.86%
Appearance:Solid
Color:White to Yellow
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Product Introduction

Bioactivity
Description
N-Methylnicotinamide is one of the endogenous metabolites that ameliorates endothelial dysfunction.
In vitro
To this aim, 7- and 30-day-old plants were treated with 0, 120, 240, 500, and 1,000 μM Pb during 10 days. The content of Medicarpin was determined by HPLC, and the extent of Medicarpin production was deduced from the result of semiquantitative RT-PCR performed on PAL, CHS, and VR genes. HPLC results indicated that Medicarpin concentration has been reduced in the roots, while its exudation to the culture medium has been increased. RT-PCR results indicated that the transcript levels of PAL, CHS, and VR genes have not been affected following Pb stress in seedlings. At the vegetative stage, transcript levels of PAL and CHS genes have been reduced in the roots. However, the transcript level of VR gene increased at 120 and 240 μM Pb, while it decreased at higher concentrations. In the shoot, the transcript levels of PAL, CHS, and VR genes were increased following increased concentration of lead in the medium[1]
Synonyms(-)-Medicarpin
Chemical Properties
Molecular Weight270.28
FormulaC16H14O4
Cas No.32383-76-9
Smiles[H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1cc(OC)ccc21
Relative Density.1.319g/cm3
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22.5 mg/mL (83.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6999 mL18.4993 mL36.9987 mL184.9933 mL
5 mM0.7400 mL3.6999 mL7.3997 mL36.9987 mL
10 mM0.3700 mL1.8499 mL3.6999 mL18.4993 mL
20 mM0.1850 mL0.9250 mL1.8499 mL9.2497 mL
50 mM0.0740 mL0.3700 mL0.7400 mL3.6999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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