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L-902688
(Synonyms: L902688, L 902688) Copy Product Info
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Synonyms: L902688, L 902688
Catalog No. T15690 Copy Product Info
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L-902688 is a potent, highly selective and orally active EP4 receptor agonist with a Ki value of 0.38 nM and an EC50 value of 0.6 nM. Its selectivity for the EP4 receptor is more than 4000-fold higher than that for other EP receptors and prostanoid receptors.
Cas No. 634193-54-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 500 µg | $397 | Inquiry | Inquiry | |
| 1 mg | $768 | In Stock | - | |
| 5 mg | $3,420 | Inquiry | Inquiry | |
| 10 mg | $5,920 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-902688 is a potent, highly selective and orally active EP4 receptor agonist with a Ki value of 0.38 nM and an EC50 value of 0.6 nM. Its selectivity for the EP4 receptor is more than 4000-fold higher than that for other EP receptors and prostanoid receptors. |
| Targets & IC50 | EP4:0.6 nM (EC50), EP4:0.38 nM (Ki) |
| In vitro | Methods: Human umbilical vein endothelial cells (HUVECs) were treated with 1 μM L-902688 for 24 hours to detect its effect on the expression of Twist and α-smooth muscle actin (α-SMA) induced by TGF-β. Results: L-902688 (1 μM, 24 h) could significantly inhibit the TGF-β-induced upregulation of Twist and α-SMA expression in HUVECs [1]. |
| In vivo | Methods: Adult male SD rats were intraperitoneally injected with L-902688 at a dose of 0.25–1 μg/kg per day once daily for 3 weeks. The degree of right ventricular fibrosis was evaluated in a monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) model. Results: L-902688 (0.25–1 μg/kg/day, intraperitoneal injection, once daily for 3 consecutive weeks) could attenuate right ventricular fibrosis in MCT-induced PAH rats [1]. |
| Synonyms | L902688, L 902688 |
| Molecular Weight | 419.47 |
| Formula | C21H27F2N5O2 |
| Cas No. | 634193-54-7 |
| Smiles | C(=C/[C@H](C(F)(F)C1=CC=CC=C1)O)\[C@@H]2N(CCCCCCC=3NN=NN3)C(=O)CC2 |
| Relative Density. | no data available |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: L-902688 chemical structure | L-902688 in vivo | L-902688 in vitro | L-902688 formula | L-902688 molecular weight
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