Anti-TLR3/CD283 Antibody (CNTO5429) is a potent neutralizing antibody targeting human Toll-like receptor 3 (TLR3), acting by interfering with the binding of double-stranded RNA (dsRNA) to the receptor's extracellular domain. The compound is an essential tool for investigating immune responses induced by endogenous or viral dsRNA, aiming to downregulate the production of pro-inflammatory cytokines by blocking the TLR3 signaling pathway.