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Solifenacin

Name: Solifenacin
Brand: TargetMol
SKU: T8147
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8147Cas No. 242478-37-1

Alias YM905 free base

Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.

Solifenacin

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Purity: 99.87%

Catalog No. T8147Alias YM905 free baseCas No. 242478-37-1

Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$39	In Stock	In Stock
50 mg	$58	In Stock	In Stock
100 mg	$93	In Stock	In Stock
500 mg	$221	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.
Targets&IC50	M3 mAChR:8 (ki), M2 mAChR:6.9 (ki), M1 mAChR:7.6 (ki)
In vivo	Solifenacin exerts minimal inhibitory effects on salivary and cardiac responses at a dosage of 630 nmol/kg (0.3 mg/kg), achieving inhibition levels of 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At lower doses (63 and 210 nmol/kg or 0.03 and 0.1 mg/kg), Solifenacin slightly enhances saliva secretion. Conversely, it reduces bladder responses by 40% at 210 nmol/kg (0.1 mg/kg) and completely suppresses them at 2100 nmol/kg (1 mg/kg). Intravenously administered, Solifenacin (0.01 to 0.3 mg/kg) progressively augments bladder capacity and the volume of urine voided when dosed at 0.03 mg/kg or higher, without impacting residual volume or micturition pressure at any administered dosage.
Synonyms	YM905 free base

Chemical Properties

Molecular Weight	362.46
Formula	C₂₃H₂₆N₂O₂
Cas No.	242478-37-1
Smiles	C(O[C@@H]1C2CCN(C1)CC2)(=O)N3[C@H](C=4C(CC3)=CC=CC4)C5=CC=CC=C5
Relative Density.	1.24g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (151.74 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7589 mL	13.7946 mL	27.5893 mL	137.9463 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL	27.5893 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL	13.7946 mL
20 mM	0.1379 mL	0.6897 mL	1.3795 mL	6.8973 mL
50 mM	0.0552 mL	0.2759 mL	0.5518 mL	2.7589 mL
100 mM	0.0276 mL	0.1379 mL	0.2759 mL	1.3795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc