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Flibanserin
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Catalog No. T4297Cas No. 167933-07-5
Alias Girosa, BIMT-17BS, BIMT-17
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has not been linked to instances of clinically apparent acute liver injury.
Flibanserin
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Purity: 99.93%
Catalog No. T4297Alias Girosa, BIMT-17BS, BIMT-17Cas No. 167933-07-5
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has not been linked to instances of clinically apparent acute liver injury.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $34 | In Stock | In Stock | |
| 10 mg | $59 | In Stock | In Stock | |
| 25 mg | $109 | In Stock | In Stock | |
| 50 mg | $197 | In Stock | In Stock | |
| 100 mg | $255 | In Stock | In Stock | |
| 200 mg | $378 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
Flibanserin AI Summary
Flibanserin exhibits a multifaceted bioactivity profile, notably including strong interactions with serotonin-related receptors and antiviral properties. It shows a high binding affinity to the human 5-HT1A receptor with a Ki of 11.75 nM and functions as an agonist with an EC50 of 630.96 nM and an Emax of 72.0% relative to 5-hydroxytryptamine. In vivo, it demonstrates antidepressant-like activity in rats, with an ED50 greater than 320 mg/kg in a forced swimming test and inducing forepaw treading and flat body posture at ED50 values greater than 40 mg/kg and 20 mg/kg, respectively.
In the context of antiviral activity, Flibanserin inhibits SARS-CoV-2 cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, with a notable inhibition of 56.47% cytotoxicity in Caco-2 cells after 48 hours. It also shows activity against the SARS-CoV-2 3CL-Pro protease at 20 µM via FRET assay, although the inhibition percentages are relatively modest (16.04% and 13.86%). The compound's effect on the USA-WA1/2020 strain of SARS-CoV-2, with a hit score of 0.2785 in HRCE cells, underscores its potential as an antiviral agent.
Furthermore, Flibanserin demonstrates inhibitory activity against human HDAC6 with stronger effects observed using commercial peptide substrates (18.44% inhibition). It also binds to various other receptors, including DRD1, DRD3, OPRM1, ADRA2A, showing its potential involvement in multiple signaling pathways. Its complex pharmacological profile includes activities as both an agonist and antagonist across different receptors and enzymes. Overall, Flibanserin is a compound of significant interest for its diverse biological activities and therapeutic potential..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has not been linked to instances of clinically apparent acute liver injury. |
| Targets&IC50 | 5-HT1A:1 nM(Ki), D4 receptor:4-24 nM(Ki), 5-HT2A:49 nM(Ki) |
| Synonyms | Girosa, BIMT-17BS, BIMT-17 |
| Molecular Weight | 390.4 |
| Formula | C20H21F3N4O |
| Cas No. | 167933-07-5 |
| Smiles | C(CN1CCN(CC1)C2=CC(C(F)(F)F)=CC=C2)N3C=4C(NC3=O)=CC=CC4 |
| Relative Density. | 1.292 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (128.07 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.12 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
sexualSerotonin Receptorprefrontal cortexorally activeno cytotoxicityNHSF cell lineneurotransmittermidbrainInhibitorinhibithypoactive sexual desire disorderhypoactiveHSDDhippocampusFlibanserinDP2DP1DopamineReceptorDopamine ReceptordisorderdesireD4BIMT17BIMT 17antidepressantantianxietyaffinity5-hydroxytryptamine Receptor5HTReceptor5-HT2A5-HT1A5-HT Receptor5HT Receptor
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