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GSK3179106

Name: GSK3179106
Brand: TargetMol
SKU: T5491
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5491Cas No. 1627856-64-7

GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM

GSK3179106

🥰Excellent

Purity: 99.90%

Catalog No. T5491Cas No. 1627856-64-7

GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$227	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$496	-	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.90%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM
Targets&IC50	RET:0.4 nM
In vitro	The effect of GSK3179106 on human and rat RET enzymatic activity and motesanib on human RET enzymatic activity was determined in an in vitro biochemical homogeneous time-resolved fluorescence (HTRF) assay.
In vivo	GSK3179106 (3 or 10 mg/kg; orally; BID for 3.5 days) reduces the visceromotor response (VMR) compared to rats administered an acetic acid enema and treated with a vehicle.

Chemical Properties

Molecular Weight	467.41
Formula	C₂₂H₂₁F₄N₃O₄
Cas No.	1627856-64-7
Smiles	CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (213.94 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1394 mL	10.6972 mL	21.3945 mL	106.9725 mL
5 mM	0.4279 mL	2.1394 mL	4.2789 mL	21.3945 mL
10 mM	0.2139 mL	1.0697 mL	2.1394 mL	10.6972 mL
20 mM	0.1070 mL	0.5349 mL	1.0697 mL	5.3486 mL
50 mM	0.0428 mL	0.2139 mL	0.4279 mL	2.1394 mL
100 mM	0.0214 mL	0.1070 mL	0.2139 mL	1.0697 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc