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P-2281

Name: P-2281
Brand: TargetMol
SKU: T28285
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28285Cas No. 1112994-35-0

Alias P2281, P 2281

P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis.

P-2281

🥰Excellent

Purity: 99.95%

Catalog No. T28285Alias P2281, P 2281Cas No. 1112994-35-0

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$167	In Stock
10 mg	$239	In Stock
25 mg	$410	In Stock
50 mg	$541	In Stock
100 mg	$742	In Stock
200 mg	$1,000	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis.
Synonyms	P2281, P 2281

Chemical Properties

Molecular Weight	209.63
Formula	C₉H₈ClN₃O
Cas No.	1112994-35-0
Smiles	N(C(C(C)Cl)=O)C=1C=CC(C#N)=NC1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (238.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7703 mL	23.8515 mL	47.7031 mL	238.5155 mL
5 mM	0.9541 mL	4.7703 mL	9.5406 mL	47.7031 mL
10 mM	0.4770 mL	2.3852 mL	4.7703 mL	23.8515 mL
20 mM	0.2385 mL	1.1926 mL	2.3852 mL	11.9258 mL
50 mM	0.0954 mL	0.4770 mL	0.9541 mL	4.7703 mL
100 mM	0.0477 mL	0.2385 mL	0.4770 mL	2.3852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc