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P-2281

Name: P-2281
Brand: TargetMol
SKU: T28285
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28285Cas No. 1112994-35-0

Alias P2281, P 2281

P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis.

P-2281

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Purity: 99.98%

Catalog No. T28285Alias P2281, P 2281Cas No. 1112994-35-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	-	In Stock
5 mg	$167	-	In Stock
10 mg	$239	-	In Stock
25 mg	$410	-	In Stock
50 mg	$541	-	In Stock
100 mg	$742	-	In Stock
200 mg	$1,000	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

P-2281 AI Summary

P-2281 inhibits mTOR in human H460 cells by 70.0% at a concentration of 10 μM, as assessed through the inhibition of FCS-induced phosphorylation of p70S6K1 by ELISA. When administered intraperitoneally to mice, it achieves a Cmax of 180,000.0 nM at a dose of 100 mg/kg and a Cmax of 30,000.0 nM at a dose of 15 mg/kg in mouse plasma..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis.
Synonyms	P2281, P 2281

Chemical Properties

Molecular Weight	209.63
Formula	C₉H₈ClN₃O
Cas No.	1112994-35-0
Smiles	N(C(C(C)Cl)=O)C=1C=CC(C#N)=NC1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (238.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7703 mL	23.8515 mL	47.7031 mL	238.5155 mL
5 mM	0.9541 mL	4.7703 mL	9.5406 mL	47.7031 mL
10 mM	0.4770 mL	2.3852 mL	4.7703 mL	23.8515 mL
20 mM	0.2385 mL	1.1926 mL	2.3852 mL	11.9258 mL
50 mM	0.0954 mL	0.4770 mL	0.9541 mL	4.7703 mL
100 mM	0.0477 mL	0.2385 mL	0.4770 mL	2.3852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc