cGAS-IN-7

Name: cGAS-IN-7
Brand: TargetMol
SKU: T213997
Rating: 4.5 (1 reviews)

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cGAS-IN-7 is an inhibitor of the cyclic GMP-AMP synthase (cGAS) with an IC50 value of 0.66 μM for human cGAS. It moderately reduces cGAMP levels in THP1 cells and is applicable in Alzheimer's disease research.

cGAS-IN-7

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	cGAS-IN-7 is an inhibitor of the cyclic GMP-AMP synthase (cGAS) with an IC50 value of 0.66 μM for human cGAS. It moderately reduces cGAMP levels in THP1 cells and is applicable in Alzheimer's disease research.
In vitro	cGAS-IN-7 (compound 6) exhibits varying degrees of cGAS inhibition at concentrations of 10 μM and 20 μM over a period of 3 hours in cell-free assays. At concentrations of 10 μM, 30 μM, and 100 μM for 16 hours, cGAS-IN-7 significantly inhibits cGAS activity and downstream signaling in THP1 Dual cells. It reduces IFN levels but does not affect NF-κB levels at a concentration of 100 μM.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.